Biomedical Analysis of Proteins and Proteomes by Mass Spectrometry

Dear Colleagues,

Proteins are implicated in nearly every biological process; therefore, their comprehensive analysis at the cellular level provides a global view of how these molecules operate and interact, both with one another and with other molecules, to build and sustain a functional biological system. Transcriptional and translational responses to various stimuli in biological systems result in functional changes to the proteome increasing the complexity of this area of research.

Modern state-of-the-art technologies based on mass spectrometry (MS) have nowadays become the technology of choice for assessing protein diversity and function. Moreover, evolving concepts have the potential to improve the present-day features of proteomics. Metaproteomics has emerged as a subfield of proteomics, and provides essential information for the global characterization of a microbiome system at a functional level, linking the bacterial proteome with human health and certain pathological conditions. Pharmacoproteomics and toxicoproteomics are critical for elucidating targetable mechanisms of action for both the drug development and monitoring of therapy efficacy and toxicity, in order to apply precision medicine to the clinic. Recent developments in MS instrumentation, fragmentation strategies, high-throughput workflows, and software used for data handling have made it possible to analyze intact glycoproteins and identify protein glycosylation patterns so that glycoproteomic assays can aid both basic and translational research.

The use of MS-based complementary technologies in clinical proteomics offered valuable resources for biomarker discovery and for understanding the mechanisms involved in disease development and progression, as well as therapeutic intervention. We hope that in the near future, MS-based proteomics should significantly improve our ability to carry out early diagnoses, personalized therapy, and monitor response to therapy.

Since the interaction between proteins and other biomolecules is capable of regulating a multitude of cellular processes, disciplines realted to proteomics will also be explored.

In this Special Issue, we would like to invite original articles and reviews on all aspects of MS-based proteomics workflows and their applications in various areas of biomedical research, covering not only basic biology and biochemical aspects, but also providing new insights into the molecular mechanisms in health and diseases.

Dr. Alina Florina Serb
Dr. Ramona Curpân
Dr. Liliana Cseh
Guest Editors

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