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Special Issue "Polymyxins"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 15 December 2018

Special Issue Editor

Guest Editor
Prof. Dr. Francesc Rabanal Anglada

Research PI, Organic chemistry department, Universitat de Barcelona, 08028 Barcelona, Spain
Website | E-Mail
Interests: Design and chemical synthesis of AMPs (Polymyxin B) and peptidomimetics; β-Lactam antibiotics; Antimicrobial resistance; Gram-negative bacterial infections

Special Issue Information

Dear Colleagues,

Polymyxins, which include colistin (polymyxin E), are a class of cyclic lipopeptide antibiotics that are highly active against therapeutically relevant Gram-negative bacteria, such as Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli. Discovered in 1947, polymyxins became available in the 1950s and were used in the clinic for a couple of decades. At the end of the 1970s, though, they were progressively abandoned due to neurotoxicity and nephrotoxicity concerns and because less toxic therapeutic options became available.

The emergence of bacteria that are resistant to almost all available antibiotics and the fact that no novel drugs have been designed or discovered in the last years, have renewed the interest in this old class of antibiotics and are currently used as last-line therapy for otherwise untreatable infections.

This Special Issue is devoted to recent developments in the field of polymyxins research and development. The scope is broad, including chemistry of polymyxins, design of new analogues, evaluation of microbiological, pharmacological, and toxicological profiles, mechanism of action, resistance, antibiofilm properties, antimicrobial synergy, sensitization, nanoconjugation and in vitro and in vivo assays.

The idea of this issue is to become a platform to update and share the knowledge in this important field of antibiotic research and development.

Prof. Francesc Rabanal Anglada
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • polymyxins
  • colistin
  • chemistry
  • design
  • development
  • activity
  • toxicity
  • pharmacology
  • biomarkers
  • probes
  • nanoconjugation
  • sensitization
  • permeabilization
  • polymyxin/colistin resistance
  • antibiofilm activity
  • biophysics
  • mechanism of action
  • in vitro assays
  • in vivo assays

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Author: Martti Vaara
Affiliation: University of Helsinki Central Hospital, Finland
Author: Jean Marc Rolain
Affiliation: Aix Marseille Universite, IHU-Méditerranée Infection, Marseille, France 
Author: Michele Visentin
Affiliation: UniversitatsSpital Zurich, Department of Clinical Pharmacology and Toxicology, Zurich, Switzerland 
Author: Bela Kocsis
Affiliation: Semmelweis Egyetem, Institute of Medical Microbiology, Budapest, Hungary 
Author: Paul B. Savage
Affiliation: Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA
Author: Lei Yin
Affiliation: State Key Laboratory of Virology, Wuhan University, China
Author: Shaolin Wang
Affiliation: China Agricultural University, China 
Authors: L. Sorlí and J.P. Horcajada
Affiliation: Hospital del Mar, Spain
Author: Zhiliang Yu
Affiliation: Zhejiang University of Technology
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