Antimicrobial Peptides and Peptidomimetics Ⅱ
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 223
Special Issue Editor
Special Issue Information
Dear Colleagues,
Human beings have been contending with infections caused by various pathogens for thousands of years, with enormous impacts on our lives and society. There are still no effective treatments for many known infectious diseases, such as COVID-19. Thus, increasingly more research is being devoted to the development of novel therapeutic agents for anti-infectives.
Antimicrobial peptides (AMP), found in almost all organisms, can directly affect pathogens or possess immunomodulatory properties. The distinct mechanism of action (MoA) yields AMPs with not only potent activities targeting different microbes, but also robustness towards bacterial resistance. Until now, progressively more natural AMPs have been discovered, with the investigation of their activities further serving as a template for propelling the development of novel designs in synthetic therapeutics. AMPs have provoked considerable insights from research groups worldwide; however, their low stability in physiochemical conditions and susceptibility to enzymatic degradation still hinder the clinical implementation of AMPs, with only a few currently in use in clinical trials.
This Special Issue is aimed at recent advances in the synthesis, mechanistic understanding and applications of antimicrobial peptides (and peptidomimetics) in the development of new agents for the treatment of microbial infections.
Dr. Tzong-Yi Lee
Guest Editor
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Keywords
- microbial infection (bacterial, fungal, virus and parasitic)
- antimicrobial peptides
- peptoids
- peptidomimetics
- synthesis
- mode of action
- peptide structure and functions
- biochemistry
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