Alternative Drug Therapy-Cyanobacterial Metabolites
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 309
Special Issue Editors
Interests: isolation and structural elucidation of new leads compounds as anti-microbial, anti-inflammatory, and anti-cancer drugs; exploration of the QSI and the QS molecules for development of antivirulence drug therapy; cyanobacteria as a source of novel lead compounds and toxins; advances in the detection of toxins in fresh water
Special Issues, Collections and Topics in MDPI journals
Interests: isolation and structural elucidation of new leads compounds as anti-microbial, anti-inflammatory, and anti-cancer drugs; exploration of the QSI and the QS molecules for development of antivirulence drug therapy; cyanobacteria as a source of novel lead compounds and toxins; advances in the detection of toxins in fresh water
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The understanding of how intercellular microbial communication is involved in bacterial pathogenesis has revealed the potential for alternative strategies to treat bacteria-mediated diseases. Quorum sensing (QS) regulates coordinated responses across a bacterial population, and in many cases, the responses elicited by QS signals contribute directly to pathogenesis through the synchronized production of virulence determinants, such as toxins and proteases. QSI compounds inactivate QS via different quenching mechanisms, including enzymatic inactivation of the signal molecule, inhibition of signal biosynthesis, and inhibition of signal detection. Cyanobacteria being one of the prolific sources of chemical diverse bioactive natural products and toxins suggests it to be a potential reservoir for isolation and structural elucidation of novel antimicrobials that are based on the QSI mechanism of action. Further, the role of QS molecules towards the development of co-habitation in non-axenic cyanobacterial cultures is appreciated.
This Special Issue of Molecules will cover the entire field of QS and QSI agents. In particular, studies on the molecular mechanisms of these compounds are especially encouraged.
Dr. Kumar Saurav
Dr. Subhasish Saha
Guest Editors
Manuscript Submission Information
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Keywords
- Cyanobacteria
- Quorum sensing
- Quorum sensing Inhibition
- Antivirulence drug therapy
- Toxins production and its detection
- Autoinducers detection
- Antimicrobial activity
- Biosynthesis of bioactive lead molecules
- Host–microbe interaction mechanism
- Dereplication strategy for metabolites
