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Molecules
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Recent Developments of the Kinugasa Reaction
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Recent Developments of the Kinugasa Reaction

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 March 2015) | Viewed by 12126

Special Issue Editor

Prof. Dr. José Marco-Contelles

E-Mail Website
Guest Editor
Laboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain
Interests: Alzheimer’s disease; biological evaluation; drug discovery; medicinal chemistry; molecular design; neurodegenerative diseases; stroke; synthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

β-Lactams are possibly one of the best known and extensively investigated heterocyclic ring systems as a result of both their biological activity as antibiotics, and their utility as synthetic intermediates. Among the different synthetic approaches for the preparation of β-lactams, the Kinugasa reaction has caught the attention of the scientific community, highlighting the great synthetic potential of this reaction. This Special Issue will contain contributions discussing all the different aspects broadly indicated by the keywords. Review articles by experts in the field will also be welcome.

Prof. Dr. José Marco-Cntelles
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Keywords

  • kinugasa reaction
  • cu-promoted catalysis
  • b-lactams
  • nitrones

Published Papers (2 papers)

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593 KiB  
Review
Kinugasa Reactions in Water: From Green Chemistry to Bioorthogonal Labelling
by Mariya Chigrinova, Douglas A. MacKenzie, Allison R. Sherratt, Lawrence L. W. Cheung and John Paul Pezacki
Molecules 2015, 20(4), 6959-6969; https://doi.org/10.3390/molecules20046959 - 16 Apr 2015
Cited by 23 | Viewed by 7749 | Correction
Abstract
The Kinugasa reaction has become an efficient method for the direct synthesis of β-lactams from substituted nitrones and copper(I) acetylides. In recent years, the reaction scope has been expanded to include the use of water as the solvent, and with micelle-promoted [3+2] cycloadditions [...] Read more.
The Kinugasa reaction has become an efficient method for the direct synthesis of β-lactams from substituted nitrones and copper(I) acetylides. In recent years, the reaction scope has been expanded to include the use of water as the solvent, and with micelle-promoted [3+2] cycloadditions followed by rearrangement furnishing high yields of β-lactams. The high yields of stable products under aqueous conditions render the modified Kinugasa reaction amenable to metabolic labelling and bioorthogonal applications. Herein, the development of methods for use of the Kinugasa reaction in aqueous media is reviewed, with emphasis on its potential use as a bioorthogonal coupling strategy. Full article
(This article belongs to the Special Issue Recent Developments of the Kinugasa Reaction)
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591 KiB  
Correction
Correction: Chigrinova, M., et al. Kinugasa Reactions in Water: From Green Chemistry to Bioorthogonal Labelling. Molecules 2015, 20, 6959-6969
by Mariya Chigrinova, Douglas A. MacKenzie, Allison R. Sherratt, Lawrence L. W. Cheung and John Paul Pezacki
Molecules 2015, 20(5), 8303; https://doi.org/10.3390/molecules20058303 - 07 May 2015
Cited by 22 | Viewed by 3820
Abstract
The authors wish to make the following correction to this paper [1]: The author name “Paul Pezacki” should be “John Paul Pezacki”. [...] Full article
(This article belongs to the Special Issue Recent Developments of the Kinugasa Reaction)
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