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Special Issue "Halogenated Nucleic Acids"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 383

Special Issue Editor

Structural Chemistry Research Group and X-ray Diffraction Laboratory, Chemistry Department, "Sapienza" University of Rome, 00191 Roma, Italy
Interests: supramolecular chemistry; crystal engineering; canonical and epigenetic nucleobases; hydrogen bond; halogen bond; X-ray single-crystal; X-ray powder diffraction; theoretical calculations; AFM
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Special Issue Information

Dear Colleagues,

Nucleic acids containing halogenated bases extend the chemical information content of DNA and RNA, which may allow engineering of novel artificial proteins. They are known to exert profound effects in a variety of microbiological and mammalian systems. Nonetheless, their role in regulating the basic functions in a cell is still largely unexplored. Moreover, over the past two decades, halogenated nucleic acids have been developed as a versatile tool for chemical fine-tuning of artificial DNA in the emerging area of synthetic biology. Indeed, halogenated base pairing may possess higher specificity and thermal stability and yield an artificially expanded genetic information system.

This Special Issue is aimed at providing selected contributions on advances in the design, synthesis, structural and theoretical characterization, and applications of halogenated nucleic acids.

Potential topics include, but are not limited to:

Synthetic DNA

Methods for labeling DNA

Structure of halogenated nucleic acids

Structure of halogenated nucleobases

Halogen bonding in nucleic acids

Antitumor activity

Prof. Dr. Gustavo Portalone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nucleic acids
  • Halogen bond
  • Hydrogen bond
  • X-ray crystal structure
  • Qtaim Supramolecular chemistry
  • Molecular recognition

Published Papers

There is no accepted submissions to this special issue at this moment.
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