Special Issue "DNA and Small Molecular Complex Crystallization"

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Biomolecular Crystals".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 2121

Special Issue Editors

Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA
Interests: biophysical chemistry; nucleic acid chemistry; chemical biology; organic chemistry; medicinal chemistry
Structural Chemistry Research Group and X-ray Diffraction Laboratory, Chemistry Department, "Sapienza" University of Rome, 00191 Roma, Italy
Interests: supramolecular chemistry; crystal engineering; canonical and epigenetic nucleobases; hydrogen bond; halogen bond; X-ray single-crystal; X-ray powder diffraction; theoretical calculations; AFM
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Special Issue Information

Dear Colleagues,

Nucleic Acid is called as the key to lives. DNA is the foundation of the life activities of human beings. However, DNAs have attracted much less attention as drug targets in structure-based drug design, partially because limited structural information of DNAs complexed with small active molecules is available. To develop more small molecules drugs based on DNA, we need to investigate the binding mechanism between DNA and small molecules deeply. Therefore, the research on the structure of DNA and complex of DNA and drugs are crucial to human health. The crystallization was a potent tool for the structural analysis of macromolecules like DNA. The crystals of a complex between DNA and small molecule may show the binding mechanism and mode clearly. We can determine the binding mode is minor groove binding, major groove binding, covalent bonds, or intercalator, also locate the hydrogen bonds, halogen bonds, interactions of water molecules, or base pairs covering scope. So, the opportunities and challenges have been faced with discovering DNA-targeting drugs for disease treatments. We seek the research and review articles about any aspect of the complex between DNA and small molecules crystallization including Screening Crystallization Conditions, Affecting Factors of DNA Crystallization, Conventional or Novel Crystallization Methods, Inducing Nucleation, DNA in the free and liganded state, DNA Duplex, Triplex, and Quadruplexes structural analysis, Detecting Crystallization Process, Structural Analysis of Crystals, Improvement of Crystallization methods, etc.

Dr. Pu Guo
Prof. Dr. Gustavo Portalone
Guest Editors

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  • DNA and Small Molecules Complex Crystallization
  • Binding between DNA and Small Molecules
  • DNA based Drug Discovery
  • Complex of DNA and Small Molecules Structural Analysis
  • DNA and Small Molecules Binding Mode Determination
  • Biophysical Research on the Binding of DNA and Small Molecules

Published Papers (1 paper)

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Quartz Crystal Microbalance Genosensing of Brettanomyces bruxellensis Yeast in Wine Using a Rapid and Efficient Drop and Collect Protocol
Crystals 2021, 11(5), 562; https://doi.org/10.3390/cryst11050562 - 18 May 2021
Cited by 1 | Viewed by 1511
A miniaturized quartz crystal microbalance (QCM) genosensor is proposed for sensitive and real-time detection of short ssDNA sequences (53 bp) or DNA extracted from Brettanomyces bruxellensis (Brett) yeast cells. The presence of Brett yeast causes a depreciation of the quality of aged fine [...] Read more.
A miniaturized quartz crystal microbalance (QCM) genosensor is proposed for sensitive and real-time detection of short ssDNA sequences (53 bp) or DNA extracted from Brettanomyces bruxellensis (Brett) yeast cells. The presence of Brett yeast causes a depreciation of the quality of aged fine wines, producing molecules of unpleasant odors and biogenic amines that are harmful to human health. More specifically, standard quartz crystal (S-QCM) and homemade 4 nm gold transmission electron microscopy (TEM)-grid patterned quartz (multi-TEM QCM) are herein proposed for biofunctionalization steps with different ssDNA sequences. By employing a rapid and efficient drop and collect protocol, the specific detection of 1 pg/µL ssDNA Brett of a short sequence and 100 ng/μL DNA of B. bruxellensis extracted from a wine sample (VR2008) is reported. Full article
(This article belongs to the Special Issue DNA and Small Molecular Complex Crystallization)
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