Special Issue "Design, Synthesis, and Structures of Modified RNA/DNA Bases"
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 1918
Interests: supramolecular chemistry; crystal engineering; canonical and epigenetic nucleobases; hydrogen bond; halogen bond; X-ray single-crystal; X-ray powder diffraction; theoretical calculations; AFM
Special Issues, Collections and Topics in MDPI journals
Special Issue in Crystals: DNA and Small Molecular Complex Crystallization
Special Issue in Molecules: Halogenated Nucleic Acids
Special Issue in Molecules: New Trend in Supramolecular Chemistry of Nucleobases
Special Issue in Crystals: Crystal Engineering of API-Based Crystals with Enhanced Properties
Naturally occurring modified nucleobases, next to the five canonical nucleobases, extend the chemical information content of DNA and RNA. They are known to exert profound effects in a variety of microbiological and mammalian systems as they can be readily incorporated into DNA. Nonetheless, their role in regulating the basic functions in a cell is still largely unexplored. Moreover, over the past two decades, chemically modified nucleobases have been developed as a versatile tool for chemical fine-tuning of artificial DNA in the emerging area of synthetic biology. Indeed, unnatural base pairing may possess higher specificity and thermal stability through a suitable design of artificial nucleobases and yield an artificially expanded genetic information system.
While the emphasis of this Special Issue on the “Design, Synthesis, and Structures of Modified RNA/DNA Bases” is the rational design of new crystal and cocrystal structures of unnatural and epigenetic nucleobases, also including their drug complexes, from X-ray and/or neutron diffraction methods, theoretical analyses are also appropriate.
As Guest Editor, it is my pleasure to invite you to contribute to this issue. Regular articles, communications, as well as reviews are all welcome.
Prof. Dr. Gustavo Portalone
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Noncanonical DNA base
- Noncanonical RNA base
- Noncanonical base-pairing
- Noncovalent interactions
- Crystal structure
- Quantum chemical calculations
- Energetics and structure prediction