Transition-Metal-Catalyzed Cross-Coupling: From Classical Methods to Modern Advances
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organometallic Chemistry".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 120
Special Issue Editors
Interests: transition metal catalysis; ligand design; gold catalysis; glycosylation reaction; medicinal chemistry
Interests: amide bonds; N-heterocyclic carbenes; Pd-NHCs; C–N activation; C–H activation; C–O activation; amide bond activation; ester activation; cross-coupling; catalysis; decarbonylative couplings; Suzuki–Miyaura; reductions; lanthanides; reductive couplings; radical chemistry; synthetic methodology; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Transition-metal-catalyzed classical cross-coupling name reactions such as Suzuki–Miyaura, Negishi, Kumada, Stille, Hiyama, Sonogashira, Heck, Buchwald–Hartwig, and Ullmann-type couplings remain indispensable for constructing C–C and C–heteroatom bonds in modern synthesis and the pharmaceutical industry. This Special Issue highlights cross-coupling chemistry “from classical methods to modern advances” with three emphases.
First, we welcome state-of-the-art developments in classical palladium catalysis, particularly strategies that address challenging substrates and transformations, improved functional-group compatibility, and practical considerations related to sustainability (e.g., reduced catalyst loading, greener solvents, improved atom economy, and scalable protocols).
Second, we encourage studies that expand beyond palladium to alternative transition-metal platforms (e.g., Au, Ni, Cu, Co, Fe) that enable distinct catalytic paradigms. Motivated by sustainability concerns and the rising cost of noble metals, we especially encourage studies that explore earth-abundant metal-catalyzed cross-coupling strategies as reliable and applicable solutions.
Third, we adopt broad transition-metal-catalyzed cross-coupling relevant reactions, including both classical cross-couplings and tandem/cascade variants that rapidly build molecular complexity.
Contributions featuring new ligand design, mechanistic investigations (experimental and/or computational), late-stage modifications, and synthetic applications for constructing bioactive molecules are particularly encouraged. Original research articles and relevant reviews are both welcome.
Dr. Pengcheng Gao
Guest Editor Assistant
Prof. Dr. Michal Szostak
Guest Editor
Manuscript Submission Information
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Keywords
- cross-coupling
- transition-metal catalysis
- palladium catalysis
- earth-abundant metals
- nickel catalysis
- copper catalysis
- cobalt catalysis
- iron catalysis
- gold catalysis
- ligand design
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