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Berry Phytoconstituents, Their Metabolites, and Interactions with Human Microbiota

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 November 2019) | Viewed by 6468

Special Issue Editors


E-Mail Website
Guest Editor
1. University of Massachusetts Dartmouth, Department of Chemistry and Biochemistry, North Dartmouth, MA, United States
2. UMass Cranberry Health Research Center
Interests: cranberry phytochemistry; metabolomics; polyphenols; colon health

E-Mail
Guest Editor
Agriculture and Agri-Food Canada, Kentville, NS, Canada
Interests: fruit phytochemistry; Vaccinium metabolites; grapes/wine

Special Issue Information

Dear Colleagues,

Berries (Vaccinium macrocarpon) have long been recognized as a source of potential health benefits ranging from urinary tract and gut health to cardiovascular benefits to anti-tumor and anti-inflammatory properties. Berry fruit, beverages, supplements and other products are now consumed worldwide as both functional foods and botanicals to support health. Its potential health benefits are linked to a growing list of bioactive constituents. These include well known flavonoids and polyphenols, but also under-represented phytoconstituents such as organic acids, triterpenoids, polysaccharides, fiber and associated metabolites. These may contribute in complementary or synergistic ways to berry’s pharmacological properties and bear further study. Variation in fruit source and composition combined with a wide variety of processing methods, such as fermentation, can yield vast differences in phytochemical profile and associated effects on the gut microbiome.

This Special Issue welcomes studies on berries, its phytochemicals and metabolites, with particular emphasis on the interactions of these components with the human microbiota. This includes changes in chemical composition as a result of processing, human metabolism or the development of value-added berry products using enzymatic, microbial and other biotransformations.

Prof. Catherine C. Neto
Dr. Shawna MacKinnon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • berry
  • berry metabolites
  • phytochemicals
  • Vaccinium macrocarpon
  • Vaccinium oxycoccus
  • microbiome
  • biotransformation

Published Papers (1 paper)

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Review

60 pages, 4980 KiB  
Review
Oligosaccharides and Complex Carbohydrates: A New Paradigm for Cranberry Bioactivity
by Christina M. Coleman and Daneel Ferreira
Molecules 2020, 25(4), 881; https://doi.org/10.3390/molecules25040881 - 17 Feb 2020
Cited by 18 | Viewed by 6216
Abstract
Cranberry is a well-known functional food, but the compounds directly responsible for many of its reported health benefits remain unidentified. Complex carbohydrates, specifically xyloglucan and pectic oligosaccharides, are the newest recognized class of biologically active compounds identified in cranberry materials. Cranberry oligosaccharides have [...] Read more.
Cranberry is a well-known functional food, but the compounds directly responsible for many of its reported health benefits remain unidentified. Complex carbohydrates, specifically xyloglucan and pectic oligosaccharides, are the newest recognized class of biologically active compounds identified in cranberry materials. Cranberry oligosaccharides have shown similar biological properties as other dietary oligosaccharides, including effects on bacterial adhesion, biofilm formation, and microbial growth. Immunomodulatory and anti-inflammatory activity has also been observed. Oligosaccharides may therefore be significant contributors to many of the health benefits associated with cranberry products. Soluble oligosaccharides are present at relatively high concentrations (~20% w/w or greater) in many cranberry materials, and yet their possible contributions to biological activity have remained unrecognized. This is partly due to the inherent difficulty of detecting these compounds without intentionally seeking them. Inconsistencies in product descriptions and terminology have led to additional confusion regarding cranberry product composition and the possible presence of oligosaccharides. This review will present our current understanding of cranberry oligosaccharides and will discuss their occurrence, structures, ADME, biological properties, and possible prebiotic effects for both gut and urinary tract microbiota. Our hope is that future investigators will consider these compounds as possible significant contributors to the observed biological effects of cranberry. Full article
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