Special Issue "Advances in Medicinal Chemistry of Antibiotics"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 August 2012).
Interests: new antibiotics; pharmacokinetics and pharmacodynamics; intracellular infection; efflux transporters
In a world of increasing resistance, we have to urgently come with new, potent, weapons. Discovery of novel antibiotic classes acting on still unexploited targets remains a challenge. Another approach that has been followed quite intensively and successfully over the last years consists in refining our knowledge of structure-activity relationships to come with molecules showing an increased intrinsic activity, a reduced susceptibility to resistance mechanisms, an improved safety profile, or a better pharmacokinetic profile.
This special issue is aimed at presenting up-to-date reviews or promising experimental data on structure-activity relationships, either for existing classes of antibiotics or for new classes of antibiotics (meaning for which there is still no drug on the market).
Prof. Dr. Françoise Van Bambeke
- structure-activity relationships
- new antibacterial targets
- activity towards multiresistant bacteria