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Special Issue "The Chemical Biology Research in France"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 1 September 2021.

Special Issue Editor

Dr. Paola Arimondo
E-Mail Website
Guest Editor
CNRS Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
Interests: chemical biology; medicinal chemistry; drug discovery in the field of epigenetics and gene regulation applied to cancer and infectious diseases

Special Issue Information

Dear Colleagues,

Chemistry at the interface of biology has played an important role in research in France since the end of the 19th century with the discoveries made by Louis Pasteur and their application to medicine and biotechnology. Chemical biology opens many possibilities for innovative findings and to develop new cutting-edge technologies to understand biology and discover, for example, new treatments for human diseases or new agronomical applications. The development of chemical reactions that occur in living systems has been a breakthrough and has enabled the observation and study of all types of biomolecules in living systems. An important application is detection: these chemical tools allow the detection and following of biological macromolecules, events and organisms in living cells and animals. With the implementation of the “omics” approaches and phenotypic technologies, chemical biology has revealed large numbers of uncharacterized potential drug targets that can be addressed with chemical probes. Chemical probes can reveal the function of a specific biomolecule without suppressing it. The effect is rapid, potentially reversible, and does not necessarily disrupt the entire interactome of the biomolecule in the biological context. Thus, they constitute a valuable toolbox for in detail studies of biological processes. Notably, when combined with a medicinal chemistry program, chemical probes can favour the emergence of drug candidates. Another explored area is the chemical modulation of biomolecules that can for example trigger the immune response and open the way to new therapeutic strategies. The present Special Issue is aimed at covering novel developments of chemical tools and chemical probes ongoing in French laboratories and their applications.

Dr. Paola Arimondo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical biology
  • France
  • chemical tools
  • detection
  • drug discovery
  • mechanism of action
  • novel targets

Published Papers (1 paper)

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Review

Review
The Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis
Molecules 2021, 26(11), 3299; https://doi.org/10.3390/molecules26113299 - 31 May 2021
Viewed by 540
Abstract
Lipid membranes are common to all forms of life. While being stable barriers that delimitate the cell as the fundamental organismal unit, biological membranes are highly dynamic by allowing for lateral diffusion, transbilayer passage via selective channels, and in eukaryotic cells for endocytic [...] Read more.
Lipid membranes are common to all forms of life. While being stable barriers that delimitate the cell as the fundamental organismal unit, biological membranes are highly dynamic by allowing for lateral diffusion, transbilayer passage via selective channels, and in eukaryotic cells for endocytic uptake through the formation of membrane bound vesicular or tubular carriers. Two of the most abundant fundamental fabrics of membranes—lipids and complex sugars—are produced through elaborate chains of biosynthetic enzymes, which makes it difficult to study them by conventional reverse genetics. This review illustrates how organic synthesis provides access to uncharted areas of membrane glycobiology research and its application to biomedicine. For this Special Issue on Chemical Biology Research in France, focus will be placed on synthetic approaches (i) to study endocytic functions of glycosylated proteins and lipids according to the GlycoLipid–Lectin (GL–Lect) hypothesis, notably that of Shiga toxin; (ii) to mechanistically dissect its endocytosis and intracellular trafficking with small molecule; and (iii) to devise intracellular delivery strategies for immunotherapy and tumor targeting. It will be pointed out how the chemical biologist’s view on lipids, sugars, and proteins synergizes with biophysics and modeling to “look” into the membrane for atomistic scale insights on molecular rearrangements that drive the biogenesis of endocytic carriers in processes of clathrin-independent endocytosis. Full article
(This article belongs to the Special Issue The Chemical Biology Research in France)
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