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Design, Modifications and Antibacterial Application of Intelligent Polymer Materials

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 2444

Special Issue Editor


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Guest Editor
School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Interests: dental materials; resin bonding agents; physical properties; antibacterial properties; caries prevention; drug carrier compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

During the last several decades, the use of antibiotics has taken a significant step toward preventing the propagation of bacterial pathogens. However, the rise of multi-drug-resistant bacteria poses a higher risk of application failures. The abuse and misuse of antibiotics has also increased. As a result, researchers have been working on developing other approaches, such as new materials and designing and modifying various compounds to increase antibacterial efficacy against pathogens. The development of intelligent materials—also known as smart materials—with multiple antibacterial components­­­ are of great importance for both fundamental research and practical applications. However, this has proven to be extremely challenging. Based on both the molecular and formulation design, polymeric intelligent materials could be specifically adapted for the demands of antimicrobial applications. Polymers are chemically stable and can be chemically and physically modified to give them some different characteristics to display antimicrobial activity. The smart polymer-based nano-carriers can also serve for the purpose of controlled drug delivery.

Therefore, this Special Issue of Molecules will serve as a platform for analyzing the recent advances in the Design, Modifications and Antibacterial Application of Intelligent Polymer Materials. I kindly invite you to submit contributions in the form of short communications, original research articles, and review papers.

Prof. Dr. Fusun Ozer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • natural compounds or derivatives
  • target treatment
  • acid producing bacteria
  • physical properties
  • pH-sensitive
  • antibacterial activity
  • drug carrier

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Published Papers (1 paper)

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Research

18 pages, 4363 KiB  
Article
Antimicrobial Denture Material Synthesized from Poly(methyl methacrylate) Enriched with Cannabidiol Isolates
by Kazi Tahsin, William Xu, David Watson, Amin Rizkalla and Paul Charpentier
Molecules 2025, 30(4), 943; https://doi.org/10.3390/molecules30040943 - 18 Feb 2025
Viewed by 2011
Abstract
Cannabidiol (CBD), derived from the Cannabis plant, has shown potential in dentistry for its antimicrobial properties, particularly against oral bacteria. Denture-associated infections, a common issue among denture wearers, present a challenge in antimicrobial enhancements to poly(methyl methacrylate) (PMMA), the primary material for dentures [...] Read more.
Cannabidiol (CBD), derived from the Cannabis plant, has shown potential in dentistry for its antimicrobial properties, particularly against oral bacteria. Denture-associated infections, a common issue among denture wearers, present a challenge in antimicrobial enhancements to poly(methyl methacrylate) (PMMA), the primary material for dentures due to its favorable physical and aesthetic qualities. To address this, researchers developed PMMA denture coatings infused with CBD nanoparticles. The CBD coatings were synthesized using UV curing and characterized via 1H NMR, SEM, and FTIR spectroscopies. Antimicrobial activity was assessed against Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. CBD demonstrated significant bactericidal effects on Gram-positive bacteria with a minimum inhibitory concentration (MIC) of 2–2.5 µg/mL and a minimum bactericidal concentration (MBC) of 10–20 µg/mL but was ineffective against planktonic Gram-negative bacteria. However, biofilm studies revealed a 99% reduction in biofilm growth for both Gram-positive and Gram-negative bacteria on CBD-infused PMMA compared to standard PMMA. The CBD disrupted bacterial cell walls, causing lysis. Dissolution studies indicated effective release of CBD molecules, crucial for antimicrobial efficacy. This study highlights CBD’s potential for antibiotic-free denture coatings, reducing dental biofilms and plaque formation, and improving oral health outcomes. Full article
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