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The Application of Nanomaterials in Cancer Diagnostics and Therapy

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 5247

Special Issue Editor


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Guest Editor
Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Interests: nanomedicine; nanochemistry; nanotechnology in drug delivery; nanomaterials; medical microbiology

Special Issue Information

Dear Colleagues,

Cancer is a leading cause of death and poor quality of life globally. Even though several strategies have been devised to reduce deaths, reduce chronic pain and improve the quality of life, there remains a shortfall in the adequacies of these cancer therapies. Among the cardinal steps towards ensuring optimal cancer treatment are the early detection of cancer cells and drug application with high specificity to reduce toxicities. Due to increased systemic toxicities and refractoriness with conventional cancer diagnostic and therapeutic tools, other strategies including nanotechnology are being employed to improve diagnosis and mitigate disease severity. Over the years, anticancer agents based on nanotechnology have been used for several cancer types to reduce the invasiveness of cancerous cells while sparing healthy cells at the target site. Nanomaterials including carbon nanotubes, polymeric micelles and liposomes have been used in cancer drug design where they have shown considerable pharmacokinetic and pharmacodynamic benefits in cancer diagnosis and treatment. In this Special Issue, we outline the commonly used nanomaterials which are employed in cancer diagnosis and therapy and highlight the suitability of these nanomaterials for cancer management based on their physicochemical and biological properties.

Dr. Mahmood Barani
Guest Editor

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Keywords

  • nanomaterials
  • nanotechnology
  • cancer
  • diagnosis
  • treatment

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Published Papers (1 paper)

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Review

25 pages, 3928 KiB  
Review
Management of Brain Cancer and Neurodegenerative Disorders with Polymer-Based Nanoparticles as a Biocompatible Platform
by Mehdi Bazi Alahri, Alhawarin Jibril Ibrahim, Mahmood Barani, Hassan Arkaban, Seyedeh Malahat Shadman, Soodeh Salarpour, Payam Zarrintaj, Javad Jaberi and Abduladheem Turki Jalil
Molecules 2023, 28(2), 841; https://doi.org/10.3390/molecules28020841 - 14 Jan 2023
Cited by 18 | Viewed by 4752
Abstract
The blood–brain barrier (BBB) serves as a protective barrier for the central nervous system (CNS) against drugs that enter the bloodstream. The BBB is a key clinical barrier in the treatment of CNS illnesses because it restricts drug entry into the brain. To [...] Read more.
The blood–brain barrier (BBB) serves as a protective barrier for the central nervous system (CNS) against drugs that enter the bloodstream. The BBB is a key clinical barrier in the treatment of CNS illnesses because it restricts drug entry into the brain. To bypass this barrier and release relevant drugs into the brain matrix, nanotechnology-based delivery systems have been developed. Given the unstable nature of NPs, an appropriate amount of a biocompatible polymer coating on NPs is thought to have a key role in reducing cellular cytotoxicity while also boosting stability. Human serum albumin (HSA), poly (lactic-co-glycolic acid) (PLGA), Polylactide (PLA), poly (alkyl cyanoacrylate) (PACA), gelatin, and chitosan are only a few of the significant polymers mentioned. In this review article, we categorized polymer-coated nanoparticles from basic to complex drug delivery systems and discussed their application as novel drug carriers to the brain. Full article
(This article belongs to the Special Issue The Application of Nanomaterials in Cancer Diagnostics and Therapy)
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