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Molecules
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Preparation and Application of Chitosan Nanoparticles and Gelatin Nanoparticles
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Preparation and Application of Chitosan Nanoparticles and Gelatin Nanoparticles

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 1710

Special Issue Editor

Prof. Dr. Minfeng Zeng

E-Mail Website
Guest Editor
Research Center of Advanced Catalytic Materials and Functional Molecular Synthesis, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, China
Interests: biological macromolecules; hybrid nanocomposites; structure–property relationship; characterization; chitosan; transition metal; heterogeneous catalysis

Special Issue Information

Dear Colleagues,

Chitosan, in which the N-acetylglucosamine moiety is a structural feature found in glycosaminoglycans, and gelatin, the partially denatured derivative of collagen, exhibit related bioactivities and biocompatibilities as their precursors. Chitosan- or gelatin-based functional biomaterials have attracted increasingly more attention. These functional biomaterials have promising perspectives in medicine, catalysis, absorbents, fine chemicals, and so on. Both biological polymers are convenient in the construction of novel nanoparticle composites. This Special Issue will mainly cover novel developments in the preparation, structure, and properties of hybrid nanocomposites based on biological macromolecules (chitosan, gelatin, and their derivatives).

Prof. Dr. Minfeng Zeng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chitosan
  • gelatin
  • nanoparticles
  • application
  • structure–property relationship

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Published Papers (1 paper)

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Research

16 pages, 3977 KiB  
Article
Lysosomal Activation Mediated by Endocytosis in J774 Cell Culture Treated with N-Trimethyl Chitosan Nanoparticles
by Brenda I. Magaña-Trejo, Aldo Y. Tenorio-Barajas, Bulmaro Cisneros, Victor Altuzar, Sergio Tomas-Velázquez, Claudia Mendoza-Barrera and Efrain Garrido
Molecules 2024, 29(15), 3621; https://doi.org/10.3390/molecules29153621 - 31 Jul 2024
Cited by 1 | Viewed by 1309
Abstract
Safety and effectiveness are the cornerstone objectives of nanomedicine in developing nanotherapies. It is crucial to understand the biological interactions between nanoparticles and immune cells. This study focuses on the manufacture by the microfluidic technique of N-trimethyl chitosan/protein nanocarriers and their interaction with [...] Read more.
Safety and effectiveness are the cornerstone objectives of nanomedicine in developing nanotherapies. It is crucial to understand the biological interactions between nanoparticles and immune cells. This study focuses on the manufacture by the microfluidic technique of N-trimethyl chitosan/protein nanocarriers and their interaction with J774 cells to elucidate the cellular processes involved in absorption and their impact on the immune system, mainly through endocytosis, activation of lysosomes and intracellular degradation. TEM of the manufactured nanoparticles showed spherical morphology with an average diameter ranging from 36 ± 16 nm to 179 ± 92 nm, depending on the concentration of the cargo protein (0, 12, 55 μg/mL). FTIR showed the crosslinking between N-trimethyl chitosan and the sodium tripolyphosphate and the α-helix binding loss of BSA. TGA revealed an increase in the thermal stability of N-trimethyl chitosan/protein nanoparticles compared with the powder. The encapsulation of the cargo protein used was demonstrated using XPS. Their potential to improve cell permeability and use as nanocarriers in future vaccine formulations was demonstrated. The toxicity of the nanoparticles in HaCaT and J774 cells was studied, as well as the importance of evaluating the differentiation status of J774 cells. Thus, possible endocytosis pathways and their impact on the immune response were discussed. This allowed us to conclude that N-trimethyl chitosan nanoparticles show potential as carriers for the immune system. Still, more studies are required to understand their effectiveness and possible use in therapies. Full article
(This article belongs to the Special Issue Preparation and Application of Chitosan Nanoparticles and Gelatin Nanoparticles)
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