Novel Small Molecules and Peptides in Drug Discovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 475
Special Issue Editors
Interests: small molecule Inhibitor; combinatorial library; antibody drug conjugate; peptide conjugate; lipid nanoparticle for gene delivery
Special Issue Information
Dear Colleagues,
Although new drug modalities, such as nanoparticles, antibodies, and nucleo-acid deliveries, have arisen in recent years, small molecule and peptide-based compounds and conjugates have remained as the major players in the drug market. For the past decade, the advances in the organic catalyst and methodology have largely expanded the diversity and scope of small molecules and peptides. The groundwork included the discovery of chiral catalysts for oxidations (2001 Nobel Prize), Suzuki coupling reaction (2010 Nobel Prize), asymmetric organocatalysis (2021 Nobel Prize), click reaction in bio-orthogonal chemistry (2022 Nobel Prize), such as copper-catalyzed azide-alkyne cycloaddition (CuACC), rendering the manifestation of numbers of novel small molecule inhibitors, libraries, and peptide conjugates. In addition, these new small molecules and peptides fill the loophole in the realm of drug discovery. The main aim of the Special Issue of Molecules, titled “Novel Small Molecules and Peptides in Drug Discovery” is to establish a platform and open forum where academic researchers and industrial scientists could continuously contribute, share, and learn the most cutting-edge technologies and ideas. This topic will be covering the advances in the new organic/inorganic synthetic methodology, the screening and optimization of novel, effective small molecule inhibitors and compound libraries, improvement in the synthesis of bioactive peptides and peptide conjugates, and the new technology for peptide mapping and protein sequence identification.
Dr. Minghao Xu
Dr. Lei Cui
Guest Editors
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Keywords
- small molecule inhibitor
- combinatorial compound library
- peptide conjugate
- organic methodology
- solid phase peptide synthesis
- organic/Inorganic catalyst
- peptide mapping and identification
- antibody-small molecule drug conjugate
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