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Exploring the Therapeutic Potential of Natural Antioxidants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 704

Special Issue Editor


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Guest Editor
College of Biomedical and Health Science, Konkuk University, Chungju 27478, Republic of Korea
Interests: aging; age-related diseases; skin and skin disorders; cosmeceuticals; nutraceuticals; natural plants; polyphenol; fermentation
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Special Issue Information

Dear Colleagues,

Oxidative stress arises from an inequality between the body's overall presence of reactive oxygen species and the biological system's capacity to neutralize these reactive compounds and efficiently mend the consequent harm. Imbalances in cellular redox equilibrium may lead to toxicity by generating peroxides and free radicals, which harm cellular constituents such as proteins, lipids, and DNA. Many reports have shown that the accumulation of oxidative stress can be the main cause of various diseases that appear as we age. To suppress this oxidative stress, antioxidant enzymes such as catalase exist in our bodies, and various antioxidants such as polyphenol exist in nature. These antioxidants are used in a variety of industries, including cosmetics and health-functional foods. Therefore, in this Special Issue, we will cover the effects of various antioxidants that exist in nature and their organic synthetic derivatives.

Dr. Dong Wook Shin
Guest Editor

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Keywords

  • oxidant stress
  • antioxidants
  • age
  • age-related disease
  • natural plants
  • polyphenol
  • fermentation

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Published Papers (1 paper)

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Research

15 pages, 3888 KiB  
Article
Pinitol Improves Lipopolysaccharide-Induced Cellular Damage in Human Dermal Microvascular Endothelial Cells
by Min Young Go, Jinsick Kim, Chae Young Jeon, Mujun Kim and Dong Wook Shin
Molecules 2025, 30(7), 1513; https://doi.org/10.3390/molecules30071513 - 28 Mar 2025
Viewed by 287
Abstract
3-O-Methyl-D-chiro-inositol (pinitol) has been reported to possess insulin-like effects and is known as one of the anti-diabetic agents for improving muscle and liver function. However, the beneficial effects of pinitol on human dermal microvascular endothelial cells (HDMECs) are not well understood. In this [...] Read more.
3-O-Methyl-D-chiro-inositol (pinitol) has been reported to possess insulin-like effects and is known as one of the anti-diabetic agents for improving muscle and liver function. However, the beneficial effects of pinitol on human dermal microvascular endothelial cells (HDMECs) are not well understood. In this study, we investigated whether pinitol could protect HDMECs from damage induced by lipopolysaccharides (LPSs), which cause various cell defects. We observed that pinitol enhanced wound healing for LPS-damaged HDMECs. We found that pinitol significantly downregulated the LPS-induced upregulation of reactive oxygen species (ROS). Pinitol also significantly restored the mitochondrial membrane potential in these cells. Immunofluorescence analysis revealed that pinitol notably reduced the nuclear localization of NF-κB in LPS-damaged HDMECs. Furthermore, we demonstrated that pinitol decreased the phosphorylation levels of the MAPK family in LPS-damaged HDMECs. Interestingly, we observed that pinitol improved tube formation in LPS-damaged HDMECs. Taken together, we suggest that pinitol exerts several beneficial effects on LPS-damaged HDMECs and may be a promising therapeutic agent for improving vascular-related skin diseases. Full article
(This article belongs to the Special Issue Exploring the Therapeutic Potential of Natural Antioxidants)
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