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Special Issue "Protein-Peptide and Protein-Small Molecule Interactions"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 March 2020

Special Issue Editor

Guest Editor
Dr. Paolo Ruzza

Institute of Biomolecular Chemistry of CNR, Padua Unit, Padova, Italy
Website | E-Mail
Interests: methods in biophysics; investigation of protein interactions by spectroscopic techniques; synthesis and conformational characterization of bioactive peptides; liquid chromatography; circular dichroism

Special Issue Information

Dear Colleagues,

 It is truly a great pleasure to put together a Special Issue on protein–peptide and protein–small molecule interactions. This important, exciting and timely topic has opened up new opportunities in drug discovery. Recently, different and innovative approaches have been developed to study these interactions, achieving important advancements of the basic sciences and medicinal chemistry. Chemists use small molecules (natural or synthetic products) as probes to identify possible therapeutically relevant protein targets. Biochemists and biologists seek to identify the endogenous metabolites that bind to specific proteins.

The purpose of this Special Issue is to attract the contribution of different researchers whose activity ranges from the development of biochemical and biophysical methods for detecting and measuring protein–peptide/small molecule interactions in vitro and in living cells, to the study of protein–ligand interfaces and the design of inhibitors, to conclude with computational approaches and internet resources for studying protein interactions.

Dr. Paolo Ruzza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Protein-peptide interactions
  • Protein-small molecule interactions
  • Hotspot residues
  • Drug design

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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