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Synthesis, Characterization and Biological, Medical and Environmental Applications of Biological Products and Bio-Based Nanomaterials or Composites

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 3744

Special Issue Editor


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Guest Editor
Department of Pharmacolog, Kazan Federal University, Kazan, Russia
Interests: natural products; green antioxidants; nanoparticles; drug development; biomedical agents

Special Issue Information

Dear Colleagues,

One of the biggest issues the world is now dealing with is environmental pollution, which is becoming worse every year and harming the planet severely and permanently. The state of the environment in the world today necessitates the development of fresh, eco-friendly solutions to global issues that meet material needs. Green Composites (GC), natural-fiber-reinforced bio-composites in which the matrix is a bio-based polymer, have demonstrated appealing features. These Green Composites (GC) are natural-fiber-reinforced bio-composites with origins from renewable sources. One of these new "green" materials' most crucial qualities is biodegradability since it enables their entry into the global market as an environmental solution. Because each raw material has unique properties and characteristics and because they are environmentally friendly, they have made it easier to incorporate them into a variety of industries, including construction, automotive, packaging, and medicine, among others. As a result, the manufacturing processes for obtaining these materials have seen significant improvements. This industry currently supports the development of green economies and the growth of global sustainability and offers some countries, especially those where these resources are rich, a sizable source of income. Due to their novel physical and chemical characteristics, nanomaterials hold a lot of promise in the battle against environmental pollution. Due to the study of the design and manufacture of metal and metal oxide materials at the nanoscale, nanotechnology is one of the most important sciences of the twenty-first century. Materials with a size of the nanometer; nanoparticles are categorized into classes such as nanocrystals, nanorods, nanowires, and nanotubes. Numerous industries employ nanomaterials. Different metals are synthesized into these materials in diverse ways. These include palladium, gold, silver, zinc, copper, and other precious metals. The medical sector, pharmacology, optics, electronics, food industry, textile industry, bioremediation of wastewater, and agricultural uses all make extensive use of it. Nanotechnology is used to build pollution monitors. As people's awareness of the need to protect non-renewable natural resources has grown, more environmentally friendly high-performance polymers and nanomaterials with innovative functionality have been developed. In this perspective, bio-based composites and nanoparticles are seen as feasible options, particularly those created from byproducts and wastes of the agro-industrial sector. These are primarily biodegradable raw materials from renewable sources that are inexpensive and would otherwise be thrown away. More and more substances are being used to purify the air, clean the water, and sanitize the soil, including iron, titanium dioxide, silica, zinc oxide, carbon nanotubes, dendrimers, polymers, etc. There are several ways to create nanoparticles. The techniques here are physical, chemical, and biological. However, physical and chemical approaches have a number of drawbacks, including being costly and releasing a large number of harmful compounds into the environment. Compared to other approaches, biological synthesis is a comparatively affordable, ecologically friendly, and secure method. It has gained popularity among researchers due to these benefits. In the biological synthesis process, reduction processes are carried out by bacteria, fungi, algae, and other plant components. Agricultural, biotechnological, and industrial uses are now possible because to recent advances in nanotechnology. Energy, electronics, reproductive technologies, medical and biological sciences, agriculture, and the conversion of food waste into energy and other valuable byproducts through enzymatic nano-bioprocessing will all be new potential domains brought about by the involvement of nanotechnology. It is also anticipated to bring up innovative opportunities in a number of fields, such as chemical and biological sensors, environmental sensors, air purifiers, filters, plant disease resistance, unfertilized perennial grasses, and water-purification technologies.

This Special Issue aims to bring together new trends and studies in bio-based nanomaterials. This Issue welcomes recent advancements in biosynthesis, characterization of bio-based composites and nanomaterials and their biological, medical and environmental applications. In this Special Issue, we invite researchers to submit their original research and review articles.

General topics include but are not confined to the below:

  • The production, characterization, and use of bio-based nanoparticles.
  • Applications of bio-based nanoparticles in medicine (drug and vaccine delivery, anticancer and antibacterial agent, and wound healing).
  • The use of bio-based nanoparticles in bioremediation and adsorption.
  • Energy and electrical uses of nanoparticles derived from biomaterials.
  • Bio-based nanoparticles used in applications related to food safety.
  • Bio-based nanomaterials for applications transforming food waste.
  • Enzymatic nano-bioprocessing applications using bio-based nanomaterials.
  • Processing of green composites.
  • Characterization and structure-property connections of green composites.
  • Synthesis and characterization of biodegradable polymer matrices for use in green composites.
  • Industrial and commercial uses of green composites; and testing of green composites.

Prof. Dr. Renad I. Zhdanov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bio nanoparticles
  • bioremediation
  • biomedicine
  • composites
  • environmental applications
  • green synthesis
  • nanobiotechnology
  • pollutant

Published Papers (2 papers)

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Research

14 pages, 4862 KiB  
Article
Green Synthesis of Silver Nanoparticles Derived from Papaver rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties
by Polat İpek, Reşit Yıldız, Mehmet Fırat Baran, Abdulkerim Hatipoğlu, Ayşe Baran, Albert Sufianov and Ozal Beylerli
Molecules 2023, 28(17), 6424; https://doi.org/10.3390/molecules28176424 - 4 Sep 2023
Cited by 1 | Viewed by 1983
Abstract
In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet–visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission [...] Read more.
In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet–visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and atomic force microscope (AFM)), structural (X-ray diffractometer (XRD) and zetasizer), and analytic (thermogravimetric/differential thermal analyzer (TGA-DTA)) characterization of the silver nanoparticles (AgNPs) produced from Papaver rhoeas (PR) L. leaf extract are presented. PR-AgNPs are generally spherical and have a maximum surface plasmon resonance of 464.03 nm. The dimensions of the manufactured nanomaterial are in the range of 1.47–7.31 nm. PR-AgNPs have high thermal stability and a zeta potential of −36.1 mV. The minimum inhibitory concentration (MIC) values (mg L−1) of PR-AgNPs on Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans are 1.50, 0.75, 3.00, 6.00, and 0.37, respectively. In the study, the cytotoxic and proliferative effects of PR-AgNPs using the MTT (3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium bromide) method on various cancer cell lines (CACO-2 (human colon adenocarcinoma cell), MCF-7 (human breast cancer cell), T98-G (glioblastoma multiforme cell), and healthy HUVEC (human umbilical vein endothelial cell)) cell lines are presented. After 24 and 48 h of the application, the half-maximum inhibitory concentration (IC50) values (μg mL−1) of PR-AgNPs on HUVEC, CACO-2, MCF-7, and T98-G lines are 2.365 and 2.380; 2.526 and 2.521; 3.274 and 3.318; 3.472 and 3.526, respectively. Comprehensive in vivo research of PR-AgNPs is proposed to reveal their potential for usage in sectors such as nanomedicine and nanochemistry. Full article
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23 pages, 4564 KiB  
Article
Insights into the Effect of Chitosan and β-Cyclodextrin Hybridization of Zeolite-A on Its Physicochemical and Cytotoxic Properties as a Bio-Carrier for 5-Fluorouracil: Equilibrium and Release Kinetics Studies
by Mashael D. Alqahtani, May N. Bin Jumah, Saleha A. AlZahrani, Ahmed A. Allam, Mostafa R. Abukhadra and Stefano Bellucci
Molecules 2023, 28(14), 5427; https://doi.org/10.3390/molecules28145427 - 15 Jul 2023
Viewed by 1272
Abstract
Synthetic zeolite-A (ZA) was hybridized with two different biopolymers (chitosan and β-cyclodextrin) producing biocompatible chitosan/zeolite-A (CS/ZA) and β-cyclodextrin/zeolite-A (CD/ZA) biocomposites. The synthetic composites were assessed as bio-carriers of the 5-fluorouracil drug (5-Fu) with enhanced properties, highlighting the impact of the polymer type. The [...] Read more.
Synthetic zeolite-A (ZA) was hybridized with two different biopolymers (chitosan and β-cyclodextrin) producing biocompatible chitosan/zeolite-A (CS/ZA) and β-cyclodextrin/zeolite-A (CD/ZA) biocomposites. The synthetic composites were assessed as bio-carriers of the 5-fluorouracil drug (5-Fu) with enhanced properties, highlighting the impact of the polymer type. The hybridization by the two biopolymers resulted in notable increases in the 5-Fu loading capacities, to 218.2 mg/g (CS/ZA) and 291.3 mg/g (CD/ZA), as compared to ZA (134.2 mg/g). The loading behaviors using ZA as well as CS/ZA and CD/ZA were illustrated based on the classic kinetics properties of pseudo-first-order kinetics (R2 > 0.95) and the traditional Langmuir isotherm (R2 = 0.99). CD/ZA shows a significantly higher active site density (102.7 mg/g) in comparison to CS/ZA (64 mg/g) and ZA (35.8 mg/g). The number of loaded 5-Fu per site of ZA, CS/ZA, and CD/ZA (>1) validates the vertical ordering of the loaded drug ions by multi-molecular processes. These processes are mainly physical mechanisms based on the determined Gaussian energy (<8 kJ/mol) and loading energy (<40 kJ/mol). Both the CS/ZA and CD/ZA 5-Fu release activities display continuous and controlled profiles up to 80 h, with CD/ZA exhibiting much faster release. According to the release kinetics studies, the release processes contain non-Fickian transport release properties, suggesting cooperative diffusion and erosion release mechanisms. The cytotoxicity of 5-Fu is also significantly enhanced by these carriers: 5-Fu/ZA (11.72% cell viability), 5-Fu/CS/ZA (5.43% cell viability), and 5-Fu/CD/ZA (1.83% cell viability). Full article
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