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Special Issue "Chemistry of Natural Organic Compounds"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (1 January 2021).

Special Issue Editor

Prof. Dr. Andrei I. Khlebnikov
E-Mail Website
Guest Editor
Kizhner Research Center, Tomsk Polytechnic University, Tomsk 634050, Russia
Interests: Organic chemistry; Drug design; Coordination chemistry; Chemistry of natural organic compounds

Special Issue Information

Dear Colleagues,

Modern organic chemistry is a complex integrated discipline that is based on enormous factual material and has a theoretical foundation using the concepts and methods of physical chemistry and physics, biological chemistry and biology, industrial chemistry and technology. Therefore, it is logical to subdivide organic chemistry into several branches, closely intertwined but at the same time quite different from each other.

One of these disciplines is the chemistry of natural compounds. Developing in the bosom of organic chemistry from the very beginning of its inception as a science, it continuously enriches the latter with new ideas, new facts, and new methods. Currently, the chemistry of natural compounds is the largest branch of organic chemistry. More than half of all research and publications in the field of organic chemistry in recent decades were devoted to substances of natural origin.

The importance of chemistry of natural compounds for solving many basic problems of natural science is difficult to overestimate. Located on the border with biological disciplines and closely related to biochemistry, the chemistry of natural compounds plays a crucial role in studying the mechanism of action of enzymes and the chemical nature of biological processes, including the transmission of inherited traits, the essence of aging processes, problems of nervous activity and other no less important questions. Natural organic compounds are extremely important for the fight against the most dangerous diseases (radiation sickness, cancer, HIV, diabetes, tuberculosis, hypertension, etc.).

This Special issue of Molecules welcomes leading scientists to submit original research papers and reviews in the field of natural organic compounds isolation, synthesis, analysis, chemical modification, and biological activity. Potential topics include but are not limited to keywords listed below.

Prof. Dr. Andrei I. Khlebnikov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Carbohydrates and polysaccharides
  • Polyphenols
  • Coumarins, flavonoids and related compounds
  • Terpenoids
  • Steroids
  • Amino acids, peptides and proteins
  • Alkaloids
  • Nucleosides, nucleotides and nucleic acids
  • Porphyrins
  • Chemical modification of natural organic compounds

Published Papers (1 paper)

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Open AccessArticle
Synthesis of Natural (−)-Antrocin and Its Enantiomer via Stereoselective Aldol Reaction
Molecules 2020, 25(4), 831; - 14 Feb 2020
Cited by 1 | Viewed by 807
The total synthesis of (−)-antrocin and its enantiomer are presented. Antrocin (−)-1 is an important natural product which acts as an antiproliferative agent in a metastatic breast cancer cell line (IC50: 0.6 μM). The key features of this synthesis [...] Read more.
The total synthesis of (−)-antrocin and its enantiomer are presented. Antrocin (−)-1 is an important natural product which acts as an antiproliferative agent in a metastatic breast cancer cell line (IC50: 0.6 μM). The key features of this synthesis are: (a) selective anti-addition of trimethylsilyl cyanide (TMSCN) to α,β-unsaturated ketone; (b) resolution of (±)-7 using chiral auxiliary L-dimethyl tartrate through formation of cyclic ketal diastereomers followed by simple column chromatography separation and acid hydrolysis; (c) substrate-controlled stereoselective aldol condensation of (+)-12 with monomeric formaldehyde and pyridinium chlorochromate (PCC) oxidation for synthesis of essential lactone core in (−)-14; and (d) non-basic Lombardo olefination of the carbonyl at the final step to yield (−)-antrocin. In addition, (+)-9 cyclic ketal diastereomer was converted to (+)-antrocin with similar reaction sequences. Full article
(This article belongs to the Special Issue Chemistry of Natural Organic Compounds)
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