Applications of Melatonin in Health and Pathology
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 197
Special Issue Editor
Interests: melatonin; antioxidants; human physiology; ischemia-reperfusion injury; free radicals; oxidative stress; organ preservation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Melatonin is an indole produced and secreted into the blood by the pineal gland in mammals. Recently, melatonin and the enzymes involved in its production have been shown to be present in numerous other tissues. Both pineal and extrapineal melatonin collaborate in the conservation of the homeostasis, protecting the tissues against multiple injuries and diseases. The indoleamine acts by binding to membrane and nuclear receptors, by interacting with cytosolic proteins and as a powerful free radical scavenger. The physiological effects of melatonin are extremely diverse, and include a wide variety of direct and indirect modulations of the endocrine, immune, and nervous systems.
Over the last three decades, a great deal of evidence has illustrated the beneficial effects of melatonin in reducing oxidative stress under a remarkably large number of circumstances. Melatonin is especially effective as an antioxidant because it utilizes a wide variety of means to reduce oxidative stress. Firstly, melatonin scavenges several toxic reactive oxygen and nitrogen reactive species, including the highly toxic hydroxyl radical. Secondly, the indoleamine also functions as an indirect antioxidant because of its ability to stimulate the expression and activity of antioxidant enzymes, which remove free radicals and their precursors.
This Special Issue aims to publish original research papers and reviews on melatonin and their roles as antioxidant anti-inflammatory and wishes to be an instrument for communication and dissemination of the most recent findings about the beneficial therapeutic implications of this indoleamine in human diseases.
Prof. Dr. Joaquín J. García
Guest Editor
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Keywords
- melatonin
- oxidative stress
- redox signaling
- antioxidant
- therapeutic implications in human diseases
