Biomolecules Interactions with Nanoparticles
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 96
Special Issue Editors
Interests: synthesis and utility of metal nanoparticles; tuning of nanoparticle surface properties; application of metal nanoparticles in surface-enhanced Raman spectroscopy; toxicity of nanoparticles; oxidative dissolution of silver nanoparticles; formation and stability of layered nanomaterials; self-assembly of nanoparticles at solid/liquid interfaces, fluorescent nanoclusters, protein fibrillation processes
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Special Issue Information
Dear Colleagues,
The dynamic development of nanotechnology has contributed to the production of diverse types of nanomaterials with well-controlled morphology, surface properties, and biological activity. Nevertheless, the interactions between engineered nanomaterials and naturally occurring biomolecules remain a central focus of researchers in various scientific fields. Despite several years of study, our knowledge of the processes of protein corona formation around hard nanoparticles still seems incomplete. Similarly, the impact of the surface properties of nanoparticles on the fibrillization processes of proteins associated with neurodegenerative diseases remains unclear. On the other hand, it has been shown that conjugating various biomolecules, such as DNA, peptides, hormones, and antibodies, with plasmonic nanoparticles, for example, allows the construction of highly sensitive and efficient sensors useful in biology and medicine. There is no doubt that both experimental and theoretical studies on the interactions between biomolecules and nanoparticles are crucial from a practical point of view. In particular, attention should be focused on determining the adsorption kinetics and mechanisms of biomolecules on the surfaces of nanoparticles. Assessing the stability and potential desorption of biomolecules from nanoparticles also requires special attention.
This Special Issue of Molecules aims to publish original high-quality research papers covering the most recent advances and comprehensive reviews addressing state-of-the-art topics in the interactions between engineered nanomaterials and biomolecules and the impacts of nanoparticles on biomolecule activity.
Topics to be covered by this Special Issue include, but are not limited to, the following:
- Design and synthesis of nanoparticles stabilized by biomolecules, e.g., amino acids, proteins, hormones, and lipids;
- Functionalization of nanoparticles with biomolecules for biological and medical applications;
- Interactions of hard metal nanoparticles with proteins, processes of protein corona formation, and adsorption of proteins on metal surfaces;
- The impact of nanoparticle size and surface properties on protein fibrillation processes;
- The influence of physicochemical properties of nanoparticles on their interactions with biological membranes;
- Tuning the biological activity of nanoparticles through their functionalization with biomolecules;
- Experimental methods for tracking ligand exchange processes on the surfaces of nanoparticles;
- New approaches for preparing biologically active conjugates of selected drugs with metal and metal oxide nanoparticles;
- New methods for determining the stability of diverse types of nanoparticles in biological fluids;
- The application of plasmonic nanoparticles to track their interactions with biomolecules using surface-enhanced spectroscopic techniques;
- Fluorescent metal nanoclusters prepared on biomolecule scaffolds;
- Biomineralization processes in the synthesis of novel nanomaterials with controlled biological activity;
- Experimental and theoretical descriptions of adsorption processes of biomolecules on surfaces of colloidal carriers;
- Conformational changes in biomolecules resulting from adsorption on nanoparticle surfaces;
- Critical assessments and future directions in research on interactions between biomolecules and nanoparticles.
In advance, we would like to gratefully acknowledge the authors and reviewers who will contribute to the elaboration of this Special Issue, the advancement of research, and the acquisition of new knowledge in the field of interactions between biomolecules and engineered nanoparticles.
Dr. Magdalena Oćwieja
Dr. Anna Barbasz
Guest Editors
Manuscript Submission Information
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Keywords
- nanoparticles
- biomolecules
- drugs
- drug–nanoparticle conjugates
- adsorption processes
- proteins
- lipids
- biological processes
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