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Study of Visible Light-Promoted Fluoroalkylation Reactions

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2086

Special Issue Editor


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Guest Editor
Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China
Interests: organic synthesis; organofluorine chemistry; drug synthesis; materials chemistry

Special Issue Information

Dear Colleagues,

Visible light-promoted fluoroalkylation reactions have great value in synthetic chemistry, particularly in the synthesis of new compounds for medicine, agriculture, materials science, and more. These reactions have advantages such as gentler reaction conditions, improved selectivity, and sustainability. This Special Issue provides an opportunity for researchers and readers to learn about this field and its potential applications. The latest advances, such as new photosensitizers, different fluoroalkylating agents, and optimized reaction conditions, are showcased, which can accelerate the development of useful molecules and help progress in various fields.

Articles and review papers are welcome and may include the following topics:

  • Development of novel photosensitizers for efficient visible light-promoted fluoroalkylation reactions;
  • Use of organic dyes as photosensitizers in visible light-promoted fluoroalkylation reactions;
  • Exploration of different fluorinated alkenes and alcohols as fluoroalkylating agents to expand the scope of the reaction;
  • Investigation of reaction mechanisms to gain insight into reaction pathways and improve reaction efficiency;
  • Optimization of reaction conditions to achieve high efficiency, selectivity, and scalability in fluoroalkylation reactions;
  • Development of green and sustainable methods for visible light-promoted fluoroalkylation reactions;
  • Application of visible light-promoted fluoroalkylation reactions in the synthesis of novel drug candidates and materials;
  • Integration of visible light-promoted fluoroalkylation reactions with other synthetic methodologies to enable the rapid synthesis of complex molecules.

Prof. Dr. Jian Hao
Guest Editor

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Published Papers (1 paper)

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Research

14 pages, 2634 KiB  
Article
Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
by Qianqian Sun, Hongxiao Li, Xingyu Chen, Jian Hao, Hongmei Deng and Haizhen Jiang
Molecules 2023, 28(8), 3578; https://doi.org/10.3390/molecules28083578 - 19 Apr 2023
Cited by 2 | Viewed by 1807
Abstract
A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition of aryldifluoromethyl radicals in situ produced from easily accessible gem-difluoroarylacetic acids to unactivated double bonds in 2-allyloxybenzaldehyde was an effective route to access a series [...] Read more.
A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition of aryldifluoromethyl radicals in situ produced from easily accessible gem-difluoroarylacetic acids to unactivated double bonds in 2-allyloxybenzaldehyde was an effective route to access a series of 3-aryldifluoromethyl-containing chroman-4-one derivatives in moderate to good yields under mild reaction conditions. Full article
(This article belongs to the Special Issue Study of Visible Light-Promoted Fluoroalkylation Reactions)
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