molecules-logo

Journal Browser

Journal Browser

Advances in Electrochemical Reactions, Mechanisms and Sensing Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Electrochemistry".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 3453

Editor


E-Mail Website
Guest Editor
School of Life and Environmental Sciences, Faculty of Science, Engineering & Built Environment, Deakin University, Burwood, VIC 3125, Australia
Interests: electrochemistry; bioelectrochemistry; spectroelectrochemistry; electrosynthesis; biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Electrochemical reactions underpin a wide spectrum of natural and technological processes, driving innovations in energy conversion, energy storage, biosensing, and environmental monitoring. These reactions regulate critical biological activities, such as cellular metabolism and neural signal transmission, while contributing to the design of advanced materials and sustainable energy technologies.

Electrochemistry has established itself as a versatile, green methodology for elucidating reaction mechanisms, engineering efficient electrocatalysts, and creating high-performance sensing platforms. Recent breakthroughs in electrochemical techniques have enabled unprecedented control over reaction pathways, leading to the synthesis of novel organic and organometallic compounds with enhanced functionalities. Furthermore, electrochemical sensors have become indispensable in fields like medical diagnostics, food safety, and environmental analysis, offering real-time, selective, and cost-effective detection solutions.

This Special Issue seeks original research articles and reviews that highlight the latest advancements in electrochemical reaction mechanisms, electrocatalysis, and sensing applications. We invite contributions that explore theoretical and experimental insights into electrochemical transformations; innovative electrode materials; sensor developments; and their applications in the healthcare, energy, and environmental fields. By promoting interdisciplinary research, this Special Issue aims to expand the frontiers of electrochemical science and its applications in real-world scenarios.

Dr. Angel A. J. Torriero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical reactions
  • reaction mechanisms
  • electrocatalysis
  • electrochemical sensing
  • organic and organometallic compounds
  • analytical electrochemistry

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 3422 KB  
Article
Thermodynamic and Kinetic Analysis of Galactose Oxidase Direct Electron Transfer on Carboxyl-Terminated SAM-Modified Gold Electrodes
by Martha Leticia Jiménez-González, Gilberto Rocha-Ortiz, Luis Gabriel Talavera-Contreras, Jose de Jésus Gómez-Guzmán, René Antaño-Lopez, Marisela Cruz-Ramírez and Luis Ortiz-Frade
Molecules 2026, 31(4), 694; https://doi.org/10.3390/molecules31040694 - 17 Feb 2026
Viewed by 695
Abstract
This study addresses the thermodynamic aspects of galactose oxidase (GAOx) adsorption and redox behavior on gold electrodes modified with self-assembled monolayers (SAMs) derived from thiocarboxylic acids, namely N-acetyl-L-cysteine (NAC), mercaptosuccinic acid (MSA), mercaptoacetic acid (MAA), and L-cysteine (Cys). The electrochemical response of GAOx [...] Read more.
This study addresses the thermodynamic aspects of galactose oxidase (GAOx) adsorption and redox behavior on gold electrodes modified with self-assembled monolayers (SAMs) derived from thiocarboxylic acids, namely N-acetyl-L-cysteine (NAC), mercaptosuccinic acid (MSA), mercaptoacetic acid (MAA), and L-cysteine (Cys). The electrochemical response of GAOx immobilized on these SAM-modified surfaces was analyzed to extract key thermodynamic parameters governing enzyme–electrode interactions, including the formal redox potential (E°), surface excess (Γ), potential of zero charge (Ezc), adsorption free energy (∆Gadd), differential capacitance (Cdl), and surface tension (γ). The results demonstrate that the nature of the terminal functional group of the SAM significantly influences the thermodynamic stabilization of GAOx at the gold interface. Shifts in the redox potential are attributed to specific coordination and electrostatic interactions between the SAM functional groups and the GAOx metal center, leading to distinct interfacial energy landscapes. Overall, the SAM-modified electrodes provide a well-defined thermodynamic framework to probe enzyme orientation, interfacial charge distribution, and stabilization of the redox-active state of GAOx during direct electron transfer. These results offer guidelines based on thermodynamic and kinetic principles for customizing enzyme–electrode interfaces, which can enhance the efficiency, stability, and consistency of third-generation electrochemical biosensors. Full article
Show Figures

Graphical abstract

19 pages, 6778 KB  
Article
Beyond the Phenothiazine Core: Mechanistic Insights into the Three-Electron Oxidation of Chlorpromazine
by Kiara T. Miller, Ashwin K. V. Mruthunjaya and Angel A. J. Torriero
Molecules 2025, 30(5), 1050; https://doi.org/10.3390/molecules30051050 - 25 Feb 2025
Cited by 2 | Viewed by 2175
Abstract
This study investigates the electrochemical oxidation mechanisms of chlorpromazine (CPZ), revealing a novel three-electron oxidation pathway that challenges the traditionally accepted two-electron paradigm, offering new insights into CPZ oxidation pathways. Using an integrated approach combining cyclic voltammetry, bulk electrolysis, UV-Vis, FT-IR, 1H-NMR [...] Read more.
This study investigates the electrochemical oxidation mechanisms of chlorpromazine (CPZ), revealing a novel three-electron oxidation pathway that challenges the traditionally accepted two-electron paradigm, offering new insights into CPZ oxidation pathways. Using an integrated approach combining cyclic voltammetry, bulk electrolysis, UV-Vis, FT-IR, 1H-NMR spectroscopy, and LC-MS/MS analysis, we demonstrate that CPZ undergoes sequential oxidation processes involving both the phenothiazine core and the tertiary amine-containing side chain. Our results highlight the critical role of side-chain oxidation in forming nor-CPZ sulfoxide, an often-overlooked metabolite, which may influence CPZ’s metabolic and pharmacological behaviour. Spectroelectrochemical data reveal stable intermediate species, providing insight into the structural rearrangements accompanying oxidation. This work offers a detailed mechanistic understanding of CPZ redox behaviour, contributing to improved interpretations of its pharmacological and metabolic properties. Full article
Show Figures

Figure 1

Back to TopTop