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Special Issue "DNA Recognition"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Prof. Dr. M. Eugenio Vázquez

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela. 15782, Santiago de Compostela, Spain
Website | E-Mail
Interests: DNA recognition; peptides; supramolecular chemistry; luminescent sensors; lanthanides

Special Issue Information

Dear Colleagues,

The development of artificial DNA-binding agents represents a significant intellectual challenge at the crossroads between biology and chemistry (structural, supramolecular, organic, inorganic chemistry, etc.) that offers ample ground for creativity. Thus, inspired by natural proteins that modulate protein expression by interacting with specific sequences, researchers have developed increasingly sophisticated DNA-binding agents that not only display comparable affinity and selectivity, but are also endowed with novel properties not found in their natural counterparts, such as light-activation, fluorescence emission, or catalytic properties.

In this Special Issue of Molecules on “DNA Recognition” we aim at providing a general overview of the field from a chemical perspective, covering from designed peptides and small organic DNA-binding agents to metal complexes and supramolecular, dynamic, and switchable systems. We hope that this Special Issue will not only provide a panorama of the field in its current form but will also offer a perspective of the challenges and developments ahead.

Dr. M. Eugenio Vázquez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DNA recognition
  • chemical biology
  • DNA-binding agents
  • molecular recognition
  • supramolecular chemistry

Published Papers (1 paper)

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Review

Open AccessReview A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context
Molecules 2019, 24(5), 946; https://doi.org/10.3390/molecules24050946
Received: 24 January 2019 / Revised: 28 February 2019 / Accepted: 1 March 2019 / Published: 7 March 2019
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Abstract
We review the preparation of new compounds with good solution and cell uptake properties that can selectively recognize mixed A·T and G·C bp sequences of DNA. Our underlying aim is to show that these new compounds provide important new biotechnology reagents as well [...] Read more.
We review the preparation of new compounds with good solution and cell uptake properties that can selectively recognize mixed A·T and G·C bp sequences of DNA. Our underlying aim is to show that these new compounds provide important new biotechnology reagents as well as a new class of therapeutic candidates with better properties and development potential than other currently available agents. In this review, entirely different ways to recognize mixed sequences of DNA by modifying AT selective heterocyclic cations are described. To selectively recognize a G·C base pair an H-bond acceptor must be incorporated with AT recognizing groups as with netropsin. We have used pyridine, azabenzimidazole and thiophene-N-methylbenzimidazole GC recognition units in modules crafted with both rational design and empirical optimization. These modules can selectively and strongly recognize a single G·C base pair in an AT sequence context. In some cases, a relatively simple change in substituents can convert a heterocyclic module from AT to GC recognition selectivity. Synthesis and DNA interaction results for initial example lead modules are described for single G·C base pair recognition compounds. The review concludes with a description of the initial efforts to prepare larger compounds to recognize sequences of DNA with more than one G·C base pairs. The challenges and initial successes are described along with future directions. Full article
(This article belongs to the Special Issue DNA Recognition)
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