Intramolecular Hydrogen Bonds

Dear Colleagues,

Intramolecular hydrogen bonds (IHBs) play a pivotal role in modern organic and inorganic, supramolecular and medicinal chemistry, influencing molecular conformation, stability, reactivity and physicochemical properties. Their ability to modulate polarity, membrane permeability and molecular recognition makes them essential for the design of functional molecules and advanced materials.

Despite significant progress, important challenges remain, including the crucial role of intramolecular hydrogen bonds and intramolecular proton transfer for the synthesis and design of coordination compounds, intramolecular H-bonding strengthened by a conjugated π-system and charge-assisted hydrogen bonding, which continue to limit our fundamental understanding and practical control of intramolecular hydrogen bonding.

Recent advances—such as intramolecular proton transfer, intramolecular hydrogen-bonded organic frameworks and organic cage compounds as well as bioactive compounds by intramolecular hydrogen bonds have greatly expanded the scope of research on IHBs, offering new tools for probing, manipulating and applying these interactions. These developments have opened new directions in areas such as conformational analysis, drug design, catalysis and materials science, while providing deeper insights into structure–property and structure–activity relationships.

This Special Issue aims to highlight the latest achievements and future perspectives in the study of intramolecular hydrogen bonds, covering all topics of the chemistry of IHBs, which seeks to emphasize the central importance of intramolecular hydrogen bonding in contemporary molecular science and its potential to address emerging scientific and technological challenges.

We look forward to your submissions.

Prof. Dr. Xuefeng Wang
Guest Editor

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