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Aptamers: From Structure to Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 258

Special Issue Editor

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Guest Editor
Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA
Interests: chemistry; aptamers; thioaptamers; cancer; 3D printing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The pace of RNA and DNA aptamer development continues to increase each year as more scientists become aware of them and we become more proficient in the methods to generate them. While a variety of novel and rapid selection techniques have been developed in recent years, the relationship between the structures and functions of aptamers should be explored in more depth. Structural studies using molecular dynamics (MD), nuclear magnetic resonance (NMR), X-ray crystallography, and ab initio (quantum mechanics) methods can provide useful information regarding the structural and binding effects of atomic substitutions (e.g., boron, sulphur, fluorine, O-methyl), formation of chimeras or particles, incorporation of unnatural or modified DNA bases, or the role of certain structure motifs, such as G-quadruplexes. This Special Issue aims to review the methods and results of past structural studies of aptamers and discuss how structures affect aptamer binding and function, as well as provide new structure–function studies.

Dr. David E. Volk
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • aptamer
  • structure
  • NMR
  • X-ray crystallography
  • function
  • ab initio

Published Papers

There is no accepted submissions to this special issue at this moment.
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