Targeted Protein Degradation Approaches
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".
Deadline for manuscript submissions: closed (31 December 2022)
Special Issue Editors
Interests: PROTACs; E3-ligase; ubiquitination; occupancy driven pharmacology; SNIPERs; PHOTACs; E3 ligase ligand-linker conjugates; molecular glues; photocaged PROTACs
Special Issues, Collections and Topics in MDPI journals
Interests: testicular cancer; infertility; Alzheimer’s disease; cancer therapeutic; neurotoxicity; brain cancer; nanoparticle research; radiation research; bioinformatics; cell and structural biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Typical medicinal chemistry approaches use potent inhibitors to inhibit protein of interest (POI). However, the continuous use of such inhibitors is compulsory to maintain sustained POI inhibition, with a high pico-to-micromolar inhibitory range, making them susceptible to resistance and on-target/off-target toxicity. On the other hand, inhibitors based on occupancy-driven pharmacology directly degrade the protein of interest, called "protein degraders," and therefore do not necessarily require nanomolar range affinity and continuous targeting of POI. In recent years, there has been success in protein degradation-based strategies. This Special Issue will give an overview of the most recent advances in the field of protein degradation and their applications. In addition, this Special Issue aims to provide selected contributions on applications, strategies, and method development regarding protein degradation.
Topics relevant to consider for this Issue, but limited to:
- Protein Degradation
- Molecular Glues
- Photoresponsive Protein degraders
- PROTACs
- SNIPERs
- LYTICs
- Ubiquitin proteasome system
Dr. Arvind Negi
Dr. Kavindra K. Kesari
Guest Editors
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