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Molecular Insights into Bioluminescence and Chemiluminescence

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Photochemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 418

Special Issue Editor


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Guest Editor
Applied Organic Chemistry, University of Applied Sciences (HTW) Dresden, Friedrich-List-Platz 1, 01069 Dresden, Germany
Interests: luminescent organic molecules

Special Issue Information

Dear Colleagues,

I am delighted to announce a Special Issue of Molecules dedicated to the exploration of the mechanisms behind bioluminescence and chemiluminescence. These natural and synthetic light-emitting processes continue to intrigue scientists due to their complex chemistry and wide-ranging applications in fields such as bioimaging, analytical chemistry, and environmental monitoring.

This Special Issue aims to compile cutting-edge research that advances our understanding of the molecular and chemical pathways responsible for light emission in biological and chemical systems. We invite you to contribute original research articles, comprehensive reviews, or short communications that shed light on the structural, kinetic, and dynamic aspects of luminescent reactions. We warmly welcome contributions that encompass both experimental investigations and theoretical analyses to shed light on these fascinating phenomena.

Topics of interest include, but are not limited to:

  • Detailed mechanistic studies of bioluminescent enzymes and substrates or chemiluminescent systems;
  • Synthesis and characterization of novel chemiluminescent or bioluminescent compounds;
  • Photophysical and photochemical analysis of luminescent systems;
  • Innovative applications of bioluminescence and chemiluminescence in sensing, imaging, and beyond;
  • Theoretical and computational studies on chemiluminescence and bioluminescence;
  • Engineering of enhanced luminescent proteins and materials.

I strongly believe that your expertise in this field would make a significant contribution to this collection. All manuscripts will undergo rigorous peer review to ensure the highest scientific quality.

For manuscript preparation and submission guidelines and deadlines, please visit the Molecules website. I am looking forward to your valuable contributions to this illuminating field of research.

Prof. Dr. Stefan Schramm
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioluminescence
  • chemiluminescence
  • chemical mechanism
  • luminescence
  • photophysics
  • photochemical processes
  • bioluminescent enzymes
  • luminescent sensing and imaging

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Published Papers (1 paper)

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Review

21 pages, 2821 KiB  
Review
Chemiluminescent 2-Coumaranones: Synthesis, Luminescence Mechanism, and Emerging Applications
by Stefan Schramm, Tim Lippold and Isabelle Navizet
Molecules 2025, 30(7), 1459; https://doi.org/10.3390/molecules30071459 - 25 Mar 2025
Viewed by 290
Abstract
Recently, 2-Coumaranones have emerged as a highly promising class of chemiluminescent compounds, distinguished by their unique structural properties that facilitate efficient light emission. This review provides a comprehensive analysis of their synthesis, structural characteristics, and chemiluminescence mechanisms, integrating historical perspectives with the latest [...] Read more.
Recently, 2-Coumaranones have emerged as a highly promising class of chemiluminescent compounds, distinguished by their unique structural properties that facilitate efficient light emission. This review provides a comprehensive analysis of their synthesis, structural characteristics, and chemiluminescence mechanisms, integrating historical perspectives with the latest advancements in the field. Beyond their intrinsic photophysical and chemical properties, 2-coumaranones have demonstrated broad utility across bioanalytical and material sciences. Notable applications include enzyme-catalyzed chemiluminescence in aqueous systems, glucose and urease-triggered detection assays, and mechano-base-responsive luminescence for stress sensing. Additionally, recent developments in chemiluminescent protective groups and their incorporation into advanced functional materials underscore the versatility of these compounds. Despite significant progress, key challenges remain, particularly in optimizing quantum yield, emission properties, and solvent compatibility for practical applications. Future research should prioritize the development of highly tunable 2-coumaranone derivatives with enhanced spectral and kinetic properties, further expanding their potential in diagnostics, bioimaging, and mechanoluminescent sensing. By addressing these challenges, 2-coumaranones could pave the way for next-generation chemiluminescent technologies with unprecedented sensitivity and adaptability. Full article
(This article belongs to the Special Issue Molecular Insights into Bioluminescence and Chemiluminescence)
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