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Metabolites from Algae: Discovery, Identification and Multifaceted Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 737

Special Issue Editors


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Guest Editor
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Naples, Italy
Interests: employment of microalgae for drug discovery and drug delivery systems; as food or feed supplements; for bioremediation purposes; novel culture strategies and technologies to increase the yields of marine primary and secondary metabolites
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Naples, Italy
Interests: novel bioactive metabolites from marine microalgae for pharmaceutical; nutraceutical and cosmeceutical applications; novel strategies to enhance industrial production of marine-derived compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine organisms are an attractive source of metabolites that can be exploited for various biotechnological purposes, including pharmaceutical, nutraceutical and cosmeceutical applications. Among them, macro- and microalgae are considered as an economic, viable and underexploited source of bioactive compounds with health-promoting properties and ecosustainable sources/devices for bioenergy and bioremediation. These organisms can be easily collected from aquatic environments and maintained on laboratory and prototype scales. Their ease of collection and/or cultivation makes them excellent test organisms for laboratory studies, allows the scale-up of the cultivation processes at pre-industrial and industrial scales, and paves the way for possible concrete applications for the production of specific metabolites of vegetal origin.

Future studies of macro- and microalgae should be aimed at discovering new methodologies and new technologies to enhance the production of their metabolites at an industrial scale.

In the above context, this Special Issue invites original scientific contributions on topics including the following:

  • Research articles on novel metabolites from algae with potential applications in drug discovery or as drug delivery systems;
  • Research articles focused on the potential of algae for bioremediation or ecosustainable energy production;
  • New strategies to optimize the yields of algae- derived metabolites;
  • Review articles representing the state of the art on the potential of macro- and/or microalgae as sources of drugs and other valuable compounds.

Dr. Angela Sardo
Dr. Giovanna Romano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine algae-derived metabolites
  • marine photosynthetic organisms as a source of drugs, nutraceuticals, cosmeceuticals
  • biotechnological applications of macro- and microalgae
  • novel strategies for industrial production of marine-derived compounds

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Published Papers (1 paper)

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Review

34 pages, 2698 KiB  
Review
Microalgae: A Promising Source of Bioactive Polysaccharides for Biotechnological Applications
by Chiara Magnabosco, Giovanna Santaniello and Giovanna Romano
Molecules 2025, 30(9), 2055; https://doi.org/10.3390/molecules30092055 - 5 May 2025
Viewed by 418
Abstract
Polysaccharides (PSs) are the most abundant carbohydrates in nature, performing essential biological functions such as immune system regulation, structural support, and cell communication. PSs from marine microalgae have gained increasing attention due to their diverse biological activities and potential applications in various fields, [...] Read more.
Polysaccharides (PSs) are the most abundant carbohydrates in nature, performing essential biological functions such as immune system regulation, structural support, and cell communication. PSs from marine microalgae have gained increasing attention due to their diverse biological activities and potential applications in various fields, including the human health sector. These natural macromolecules, primarily composed of glucose, xylose, galactose, rhamnose, and fucose, exhibit bioactive properties influenced by their molecular weight, sulfation degree, and structural complexity. Microalgal PSs can function as antiviral, antimicrobial, antioxidant, immunomodulatory, and antitumor agents, making them promising candidates for pharmaceutical and nutraceutical applications. Additionally, their physicochemical properties make them valuable as bioactive ingredients in cosmetics, serving as hydrating agents, UV protectants, and anti-ageing compounds. The production of PSs from microalgae presents a sustainable alternative to terrestrial plants, as microalgae can be cultivated under controlled conditions, ensuring high yield and purity while minimizing environmental impact. Despite their potential, challenges remain in optimizing extraction techniques, enhancing structural characterization, and scaling up production for commercial applications. This review provides an overview of the principal biological activities of PSs from eukaryotic microalgae and their possible use as ingredients for cosmetic applications. Challenges to address to implement their use as products to improve human health and wellbeing are also discussed. Full article
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