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The Applications of LC-MS/MS Technique in Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 348

Special Issue Editor

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Guest Editor
Laboratoire de Chimie et Physique - Approche Multi-échelle des Milieux Complexes (EA 4632), ICPM, Université de Lorraine, Nancy, France
Interests: pharmaceutical and plant analysis; high-resolution mass spectrometry; mass spectrometry hyphenated to gas chromatography; liquid chromatography and capillary electrophoresis; imaging mass spectrometry; LC-MS/MS
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Special Issue Information

Dear Colleagues,

Throughout the ages, our forefathers have always found in nature not only their means of subsistence, but also many active compounds, often without even knowing it, to relieve pain and cure diseases. The list of the relevant biological activities of natural products and applications is far too long for an introduction to a Special Issue, but when considering natural products, secondary metabolites of plants come immediately to mind as a source of anticancer agents, anti-inflammatory drugs, antioxidants, anti-ageing nutrients, etc. However, plant metabolites are not the only ones in this field. For instance, tetracycline is an antibiotic originally obtained from bacteria of the genus Streptomyces. Another example, this time derived from animals, is Teprotide, a nonapeptide isolated from the venom of the snake Bothrops jararaca, which was the starting point in the development of many angiotensin-converting enzyme inhibitors used to treat hypertension and heart failure. These examples show that the term “natural product“ covers primary metabolites (protein, peptides, sugars,…) as well as secondary metabolites, from procaryotic to eucaryotic organisms, and from plant to animals.

Irrespective of their origin or their activity, the identification of natural active compounds is of the greatest importance. In the last 25 years, mass spectrometry (MS), and, even more so, tandem mass spectrometry (MS/MS and MSn) coupled with liquid chromatography (LC from UHPLC to nanoLC) have become some of the most useful and powerful analytical methods for the structural elucidation and quantification of natural compounds in complex matrices. Furthermore, high-resolution MS has also become an essential tool to highlight biomarkers in a broad number of areas, from human diseases to plant defense, and many other applications.

I would like to invite you to contribute to this Special Issue dedicated to full papers, short communications, and reviews highlighting the key role of LC-MS/MS techniques in the modern analysis of natural products. This topic may cover the development of original LC-MS/MS methods (including sample treatment) for the characterization and the quantification of natural compounds in complex matrices as well as their applications in a wide range of areas according to, but not limited to, their activities (e.g., antibacterial, antioxidant, enzymatic, anti-ageing and nutraceutical, etc.), the organism (from bacteria to plant and animal) or the analytical strategy (targeted to untargeted analyses).

Prof. Dr. Patrick Chaimbault
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • LC-MS/MS
  • natural products
  • plants
  • biomarkers
  • primary and secondary metabolites
  • sample profiling
  • nutraceuticals

Published Papers

This special issue is now open for submission.
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