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Extraction, Separation and Identification of Compounds from Natural Sources—Second Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 2385

Special Issue Editor

Special Issue Information

Dear Colleagues,

Natural products are extremely popular due to their notable biological activities as well as remarkable chemical diversity. They have continued to serve as perfect templates for the discovery of new scaffolds of promising drug entities, alleviating many complex diseases. Recently, many great achievements have been sparked in the separation, isolation, identification, and structural elucidation of naturally occurring compounds. Today, the extraction and metabolic profiling of crude extracts, as well as the isolation and biosynthesis of natural compounds, have become easier than before, owing to the presence of multiple advanced and hyphenated chromatographic and spectroscopic techniques such as LC–MS (liquid chromatography coupled with mass spectrometry), LC–PDA (liquid chromatography coupled with a photodiode array detector), LC–NMR–MS (liquid chromatography coupled with nuclear magnetic resonance spectroscopy and mass spectrometry), and GC–MS (gas chromatography coupled with mass spectrometry). This Special Issue aims to shed light on the extraction, separation, isolation, and identification of secondary metabolites from natural sources, comprising plants and their essential oils or marine organisms and their associated microorganisms. This separation is performed using different techniques, including LC–MS, NMR, and GC–MS. Evaluations of their bioactivities and their probable mode of action are also recommended, which will eventually lead to the discovery of promising leads that could be incorporated into many pharmaceutical products to cure many problems. Short communications, research articles, and review articles are welcome.

Prof. Dr. Armando Zarrelli
Guest Editor

Manuscript Submission Information

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Keywords

  • natural sources
  • marine organisms
  • medicinal plants
  • essential oils
  • LC–MS (liquid chromatography coupled with mass spectrometry)
  • GC–MS (gas chromatography coupled with mass spectrometry)
  • structural elucidation
  • NMR (nuclear magnetic resonance)
  • molecular docking

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Published Papers (2 papers)

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Research

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22 pages, 9571 KiB  
Article
Differences in the Determination of Volatile Organic Compounds between Chrysanthemum morifolium Ramat. and Chrysanthemum indicum L. (Wild Chrysanthemum) by HS-GC-IMS
by Gaigai Liu, Hao Duan, Yue Zheng, Jinhong Guo, Diandian Wang and Wenjie Yan
Molecules 2024, 29(19), 4609; https://doi.org/10.3390/molecules29194609 - 27 Sep 2024
Cited by 4 | Viewed by 1016
Abstract
Chrysanthemums and wild chrysanthemums are herbs with high application value. As edible plants of the Asteraceae family, they have good antioxidant, anti-inflammatory and hepatoprotective properties. Chrysanthemums and wild chrysanthemums contain a wide variety of volatile organic compounds, and these volatile components are the [...] Read more.
Chrysanthemums and wild chrysanthemums are herbs with high application value. As edible plants of the Asteraceae family, they have good antioxidant, anti-inflammatory and hepatoprotective properties. Chrysanthemums and wild chrysanthemums contain a wide variety of volatile organic compounds, and these volatile components are the main factors contributing to the flavor differences. Therefore, in this study, we investigated the volatile components of holland chrysanthemum from Bozhou, Anhui Province, Chu-chrysanthemum from Chuzhou, Anhui Province, Gong-chrysanthemums from Huangshan, Anhui Province, Huai-chrysanthemums from Jiaozuo, Henan Province, Hang-chrysanthemum from Hangzhou, Zhejiang Province, and wild chrysanthemum from Dabie Mountain by headspace–gas chromatography–ion mobility spectrometry (HS-GC-IMS) coupled with principal component analysis (PCA). The results showed that Chrysanthemum and wild chrysanthemum contain alcohols, esters, hydrocarbons, ketones, aldehydes, acids, camphor, pyrazines and furans. Among them, alcohols, esters and hydrocarbons accounted for more than 15%. It was hypothesized that 2-methyl-1-propanol, 2-methylbutanol, 1-hexanol in alcohols and hexyl acetate, 3-methylbutyl acetate and ethyl 2-methylpropanoate in esters might be the main reasons for the alcoholic and sweet flavors of chrysanthemum and chrysanthemum officinale. Based on the principal component analysis, cluster analysis with the Euclidean distance and similarity analysis of fingerprints, it was found that there were significant differences in the volatile components in chrysanthemums from different origins, among which the differences between Chu-chrysanthemum and Hang-chrysanthemum were the most significant. In addition, as a genus of wild chrysanthemum with the same species, it contains a richer variety of volatile organic compounds, and the content of hydrocarbons and alcohols is significantly higher than that of chrysanthemum. Full article
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Review

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54 pages, 4287 KiB  
Review
Ethnobotany, Phytochemistry, and Biological Activity of Extracts and Non-Volatile Compounds from Lantana camara L. and Semisynthetic Derivatives—An Updated Review
by Jorge Ramírez, Chabaco Armijos, Nelson Espinosa-Ortega, Leydy Nathaly Castillo and Giovanni Vidari
Molecules 2025, 30(4), 851; https://doi.org/10.3390/molecules30040851 - 12 Feb 2025
Viewed by 948
Abstract
Lantana camara L., commonly known as pigeon berry, is a herbaceous plant of growing scientific interest due to the high medicinal value. In fact, despite being categorized as an invasive species, it has been used for a long time to treat different diseases [...] Read more.
Lantana camara L., commonly known as pigeon berry, is a herbaceous plant of growing scientific interest due to the high medicinal value. In fact, despite being categorized as an invasive species, it has been used for a long time to treat different diseases thanks to the many biological activities. Triterpenes, flavonoids, phenylpropanoids, and iridoid glycosides are the bioactive compounds naturally occurring in L. camara that have demonstrated anticancer, antifilarial, nematocidal, antibacterial, insecticidal, antileishmanial, antifungal, anti-inflammatory, and antioxidant properties. The aim of this review is to update the information concerning the chemistry and biological activity of L. camara extracts and their constituents, including semisynthetic derivatives, revising the literature until June 2024. We believe that the data reported in this review clearly demonstrate the importance of the plant as a promising source of medicines and will therefore stimulate further investigations. Full article
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