5-Fluorouracil
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (15 October 2008) | Viewed by 137772
Special Issue Editor
Interests: molecularly imprinted polymers; functional materials for biomedical applications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although 5-fluorouracil (5-FU) was first introduced in 1957, it remains one of the most important anticancer agents. In 5-FU, the hydrogen atom at the 5-position of uracil is replaced by a fluorine atom and the molecule was designed to occupy the active sites of enzyme targets, thereby blocking metabolism in malignant cells. Although this antimetabolite is toxic, its efficacy makes it one of the most widely used agents against solid tumors. Numerous reports by the scientific community have been devoted to 5-FU, covering a wide range of topics: preparation of innovative formulations, synthesis of 5-FU derivatives, mechanism of action studies, etc. This special issue of Molecules aims to provide an overview of the current knowledge on this important chemotherapeutic agent, as well as focus on current strategies to improve therapeutic effectiveness of this drug in the treatment of advanced disease.
Dr Francesco Puoci
Guest Editor
Keywords
- 5-fluorouracil (5-FU)
- 5-FU analogues
- fluorouracil derivatives
- prodrugs
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