molecules-logo

Journal Browser

Journal Browser

Isolation and Characterization of Biologically Active Compounds from Natural Sources

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1456

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Dunav Str. 2, 1000 Sofia, Bulgaria
Interests: the phytochemistry of Hypericum and Chenopodium species; LC-MS; the structural elucidation of natural small molecules using NMR, MS, and other spectral techniques
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Throughout ancient times, humanity has turned to nature in the quest for remedies to address a variety of ailments. This enduring tradition persists globally in diverse traditional medical systems. An array of resources, such as animal and plant species, natural minerals, mushrooms, and various microorganisms, among others, have been harnessed for the extraction of medicinal compounds. In contemporary medicine, numerous drugs, including vinblastine, vincristine, paclitaxel, papaverine, codeine, and more, trace their origins entirely to nature. Additionally, natural substances often serve as templates for the development of innovative medicinal molecules. Antibiotics stand as prime examples of natural compounds derived from micro-organisms through biotechnological methods. Marine organisms, in particular, emerge as a prolific source of structurally diverse biologically active compounds, presenting immense potential for the advancement of new drug developments.

This Special Issue of Molecules eagerly welcomes high-quality research articles and reviews that delve into the isolation and structural characterization of natural molecules, alongside their comprehensive biological and pharmacological assessments.

Dr. Paraskev Todorov Nedialkov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemicals
  • marine natural products
  • bioactive microbial metabolites
  • isolation
  • structural elucidation
  • pharmacological evaluation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

27 pages, 3713 KiB  
Article
An Unprecedented 4,8-Cycloeudesmane, Further New Sesquiterpenoids, a Triterpene, Steroids, and a Lignan from the Resin of Commiphora myrrha and Their Anti-Inflammatory Activity In Vitro
by Anna Unterholzner, Katrin Kuck, Anna Weinzierl, Bartosz Lipowicz and Jörg Heilmann
Molecules 2024, 29(18), 4315; https://doi.org/10.3390/molecules29184315 - 11 Sep 2024
Cited by 1 | Viewed by 1013
Abstract
Myrrh has a long tradition in the treatment of inflammatory diseases. However, many of its (active) constituents are still unknown. In the present study, secondary metabolites were isolated from an ethanolic extract by various separation methods (liquid–liquid partition, silica and RP18 flash chromatography, [...] Read more.
Myrrh has a long tradition in the treatment of inflammatory diseases. However, many of its (active) constituents are still unknown. In the present study, secondary metabolites were isolated from an ethanolic extract by various separation methods (liquid–liquid partition, silica and RP18 flash chromatography, CPC, and preparative HPLC), their structures were elucidated with NMR spectroscopy and mass spectrometry, and the selected compounds were tested for their effect on LPS-induced NO production by RAW 264.7 murine macrophages. Among the isolated substances are 17 sesquiterpenes (117) including the first 4,8-cycloeudesmane (1), a triterpene (38), two phytosterols (39, 40) and one lignan (43), which were previously unknown as natural products. Numerous compounds are described for the first time for the genus Commiphora. Eight of the eleven compounds tested (1, 29, 31, 32, 3437) showed a statistically significant, concentration-dependent weak to moderate anti-inflammatory effect on NO production in the LPS-stimulated RAW 264.7 macrophages in vitro. For the reference substance, furanoeudesma-1,3-diene, an IC50 of 46.0 µM was determined. These sesquiterpenes might therefore be part of the multi-target molecular principles behind the efficacy of myrrh in inflammatory diseases. Full article
Show Figures

Figure 1

Back to TopTop