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Challenges and Future Directions in Toxic Activity and Antimicrobial Application of Plant and Food Extracts

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 352

Special Issue Editors


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Guest Editor
Northwest Biological Research Center, La Paz 23096, BCS, Mexico
Interests: biotechnology; green growth; microbial pathogenesis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Northwest Biological Research Center, La Paz 23096, BCS, Mexico
Interests: aquatic biotoxins; cyanogenic glycosides; furocoumarins; lectins; mycotoxins; pyrrolizidine alkaloids; solanines and chaconine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of plant and food extracts as antimicrobial agents has gained significant attention due to the growing demand for natural and safe food preservation methods. These extracts offer a promising alternative to synthetic preservatives, which are often associated with health concerns and microbial resistance, appealing to consumer demand for safer and more sustainable food preservation methods. However, there are several challenges and future directions to consider in their application.

This Special Issue aims to cover various aspects including efficacy, safety, optimizing extraction methods, understanding mechanisms of action and eco-friendly production, and developing advanced delivery systems to enhance their application in the food industry.

Dr. Felipe Ascencio
Dr. Norma Hernández-Saavedra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • effectiveness: evaluate the efficacy of extracts under various conditions and against different pathogens
  • toxicity: investigate potential adverse effects of extracts on humans and animals
  • biodiversity: explore the diversity of plant species to discover new antimicrobial properties
  • sustainability: develop extraction and production methods that are environmentally friendly and sustainable
  • innovation: apply modern technologies, such as biotechnology, to improve the efficacy of extracts

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Published Papers (1 paper)

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Research

21 pages, 2710 KiB  
Article
Effects of Crude Shea Butters and Their Polar Extracts on Singlet Oxygen Quenching and Against Rose Bengal-Induced HaCaT Cell Phototoxicity
by Bertrand W. F. Goumbri, Olivia Jansen, Roland Marini Djang’eing’a, Michel Frederich, Rasmané Semdé, Touridomon Issa Somé, Sabine Danthine and Ange Mouithys-Mickalad
Molecules 2025, 30(6), 1360; https://doi.org/10.3390/molecules30061360 - 18 Mar 2025
Viewed by 268
Abstract
Shea butter (SB) is a raw material fat obtained from Vitellaria paradoxa C.F. Gaertn kernels. We investigated the direct and indirect protective effects of 10 traditional and industrial SBs and their polar extracts on cell-free systems using ABTS and DPPH radical scavenging assays [...] Read more.
Shea butter (SB) is a raw material fat obtained from Vitellaria paradoxa C.F. Gaertn kernels. We investigated the direct and indirect protective effects of 10 traditional and industrial SBs and their polar extracts on cell-free systems using ABTS and DPPH radical scavenging assays as well as on singlet oxygen (1O2) produced by Rose Bengal (RB) photosensitization. Their effects against RB-induced HaCaT cell phototoxicity were also explored. A spectrophotometric assay and HPLC were performed to quantify and identify phenolic content, which was between 14.16 and 82.99 ppm pyrogallol equivalent. These variations could be due to the SB origin and extraction process. These polar fractions exhibited moderate DPPH and strong ABTS radical-scavenging activity. By applying the UV–visible technique, we demonstrated that SBs and their phenolic compounds behave as 1O2 quenchers in a dose-dependent manner. Moreover, using a UVR-like model after the irradiation of RB, both polar extracts and crude SB exhibited photoprotective effects, highlighting the indirect protective action. In acellular and cellular models, SB and its polar extracts can act as a free radical scavenger against reactive oxygen species and 1O2 quenchers. Due to the maximum absorbance of SB at 280 nm and the antioxidant effect of 1O2 quenching, SB polar extracts exhibit photoprotective properties. Full article
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