Stress-Related Biomarkers: Analytical Methods and Their Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".
Deadline for manuscript submissions: 30 March 2026 | Viewed by 202
Special Issue Editor
Interests: solid-phase microextraction; chromatography; advanced glycation end products; stress hormone; biomarker; heterocyclic amines; polycyclic aromatic hydrocarbons; LC–MS/MS analysis
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Special Issue Information
Dear Colleagues,
The main types of stress that affect human health include mental and physical stress, oxidative stress, glycation stress, and immune stress. Mental and physical stress manifests itself as a physical reaction via the autonomic nervous system, endocrine system (hormones), and immune system; if it becomes chronic, it can cause mental disorders and organic and functional disorders in various organs of the body. Oxidative stress occurs when the balance between active oxygen and the antioxidant system (antioxidant substances) and antioxidant enzymes is disrupted, causing various harmful oxidative disorders due to biological oxidation. Glycation stress is a phenomenon in which proteins in the body are degraded by non-enzymatic binding with excess sugar. When enough accumulation occurs in our cells and tissues, it causes a decline in function and is a factor in aging. Immunological stress is a micro-inflammation that occurs as a defense response to infection or injury; when it becomes chronic, it can also damage healthy tissue. In order to detect such stress responses in the body at an early stage and use them to diagnose and prevent disease, it is important to analyze biomarkers specific to each type of stress. Recently, there has been progress in the development of methods for detecting and quantifying useful biomarkers from various biological samples, including saliva, hair, nails, exhaled breath, and skin gas, as well as blood and urine. Moreover, there are high expectations for the development of new sample preparation and measurement methods.
This Special Issue will cover a wide range of topics related to efficient sample preparation, separation, and analysis methods such as chromatography and electrophoresis, as well as highly sensitive and selective analytical methods such as immunoassays and mass spectrometry, in order to analyze biomarkers for the various stresses mentioned above. It will also cover the applications of these biomarker analysis methods regarding the diagnosis and analysis of the mechanisms of various diseases related to lifestyle, fatigue, aging, and stress, as well as the analysis of stress factors.
I hope that this Special Issue, which will encompass the latest topics on stress-related biomarker analysis and examples of its application to various sample analyses, will be found interesting by scientists. I also hope that it will provide impetus for the birth of further ideas and new technologies, leading to the diagnosis and prevention of stress-related diseases.
Prof. Dr. Hiroyuki Kataoka
Guest Editor
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Keywords
- biomarkers
- stress hormones
- advanced glycation end-products
- mental and physical stress
- oxidative stress
- glycation stress
- Immunological stress
- fatigue
- aging
- lifestyle-related diseases
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