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Advances in Anticancer Activity of Natural Products and Related Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 514

Special Issue Editor


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Guest Editor
Department of Pharmacology—Pharmacotherapy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania
Interests: natural products; molecular mechanisms of action; structure-activity relationships; delivery systems

Special Issue Information

Dear Colleagues,

The exploration of natural products and their derivatives has long served as a foundation in the discovery of novel anticancer agents. Nature offers a vast chemical diversity, providing compounds with unique structures and potent bioactivities. This Special Issue, entitled “Advances in Anticancer Activity of Natural Products and Related Compounds”, seeks to highlight the recent advances in the identification, characterization, and application of natural compounds in cancer research. We welcome the submission of original research articles and reviews that bring about novel insights into the molecular mechanisms of action, structure–activity relationships, and innovative delivery systems of these bioactive agents. Studies on the synergistic effects of natural products with conventional therapies, as well as investigations into overcoming drug resistance, are also encouraged. This Special Issue aims to inspire interdisciplinary collaborations and foster the development of natural product-based cancer therapeutics that will ultimately contribute to improvements in patient outcomes.

Dr. Alexandra Mioc
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural compounds
  • anticancer activity
  • bioactive compounds
  • cancer therapeutics
  • drug resistance
  • synergistic effect

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Published Papers (1 paper)

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Research

25 pages, 6142 KiB  
Article
Cancer Chemopreventive Potential of Claoxylon longifolium Grown in Southern Thailand: A Bioassay-Guided Isolation of Vicenin 1 as the Active Compound and In Silico Studies on Related C-Glycosyl Flavones
by Chuanchom Khuniad, Lutfun Nahar, Anupam D. Talukdar, Rajat Nath, Kenneth J. Ritchie and Satyajit D. Sarker
Molecules 2025, 30(15), 3173; https://doi.org/10.3390/molecules30153173 - 29 Jul 2025
Viewed by 337
Abstract
Claoxylon longifolium (Euphorbiaceae) is an indigenous vegetable that has been used in southern Thai traditional medicine and cuisine. A bioassay-guided approach was adopted to investigate the phytochemicals and chemopreventive potential of C. longifolium leaves and stems. Phytochemical investigation of the active MeOH fractions [...] Read more.
Claoxylon longifolium (Euphorbiaceae) is an indigenous vegetable that has been used in southern Thai traditional medicine and cuisine. A bioassay-guided approach was adopted to investigate the phytochemicals and chemopreventive potential of C. longifolium leaves and stems. Phytochemical investigation of the active MeOH fractions afforded six known compounds, including caffeic acid (1), isovitexin (2), and vicenins 1–3 (3–5) from leaves and hexadecanoic acid methyl ester (6) from stems. Their structures were determined by spectroscopic means. Ten constituents were tentatively identified from the oily fractions of stems by GC-MS. Non-cytotoxic concentrations of compounds 16 were identified using the MTT cell viability assay. The ability of compounds 16 at non-cytotoxic concentrations to induce Nrf2 activation, correlating to their potential chemopreventive properties, was determined using a luciferase reporter assay in the AREc32 cell line. Only vicenin 1 (3) was considered to be a potent chemopreventive compound, as it increased luciferase activity by 2.3-fold. In silico studies on compounds 25 and vitexin (16) revealed the potential of these compounds as cancer chemopreventive and chemotherapeutic agents. This study provides the first report on the chemopreventive properties of C. longifolium. All identified and isolated compounds are reported here for the first time from this species. Full article
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