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Recent Developments of Curcumin and Its Derivatives in Medicinal Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2404

Special Issue Editor


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Guest Editor
Laboratory of Antibiotics and Chemotherapeutics, Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (Unesp), São José do Rio Preto, Brazil
Interests: curcumin; curcuminoid; anticancer; antimicrobial; antibacterial; antifungal; antiprotozoal; anthelmintic
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Special Issue Information

Dear Colleagues,

Curcumin and its analogs (curcuminoids) are recognized as privileged scaffolds for drug discovery due to their concise synthesis and versatile skeleton, from which structure–activity relationships can be derived. In addition, their therapeutic potential has been confirmed by a series of successful preclinical and clinical trials. Thus, medicinal chemists continue to be fascinated and inspired by the chemical and biological properties of curcumin and its derivatives and hybrids. This Special Issue examines curcumin in detail and provides an update on the synthesis, isolation, molecular targets, pharmacological effects, and in silico studies of curcumin and its curcuminoids.

Dr. Luis Octavio Regasini
Guest Editor

Manuscript Submission Information

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Keywords

  • curcumin
  • curcuminoid
  • monoketone
  • anticancer
  • antimicrobial
  • antifungal
  • antibacterial
  • antiprotozoal

Published Papers (1 paper)

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Review

17 pages, 3074 KiB  
Review
Positive Tetrahydrocurcumin-Associated Brain-Related Metabolomic Implications
by Slavica Josifovska, Sasho Panov, Nikola Hadzi-Petrushev, Vadim Mitrokhin, Andre Kamkin, Radoslav Stojchevski, Dimiter Avtanski and Mitko Mladenov
Molecules 2023, 28(9), 3734; https://doi.org/10.3390/molecules28093734 - 26 Apr 2023
Cited by 2 | Viewed by 2148
Abstract
Tetrahydrocurcumin (THC) is a metabolite of curcumin (CUR). It shares many of CUR’s beneficial biological activities in addition to being more water-soluble, chemically stable, and bioavailable compared to CUR. However, its mechanisms of action have not been fully elucidated. This paper addresses the [...] Read more.
Tetrahydrocurcumin (THC) is a metabolite of curcumin (CUR). It shares many of CUR’s beneficial biological activities in addition to being more water-soluble, chemically stable, and bioavailable compared to CUR. However, its mechanisms of action have not been fully elucidated. This paper addresses the preventive role of THC on various brain dysfunctions as well as its effects on brain redox processes, traumatic brain injury, ischemia-reperfusion injury, Alzheimer’s disease, and Parkinson’s disease in various animal or cell culture models. In addition to its strong antioxidant properties, the effects of THC on the reduction of amyloid β aggregates are also well documented. The therapeutic potential of THC to treat patterns of mitochondrial brain dysmorphic dysfunction is also addressed and thoroughly reviewed, as is evidence from experimental studies about the mechanism of mitochondrial failure during cerebral ischemia/reperfusion injury. THC treatment also results in a dose-dependent decrease in ERK-mediated phosphorylation of GRASP65, which prevents further compartmentalization of the Golgi apparatus. The PI3K/AKT signaling pathway is possibly the most involved mechanism in the anti-apoptotic effect of THC. Overall, studies in various animal models of different brain disorders suggest that THC can be used as a dietary supplement to protect against traumatic brain injury and even improve brain function in Alzheimer’s and Parkinson’s diseases. We suggest further preclinical studies be conducted to demonstrate the brain-protective, anti-amyloid, and anti-Parkinson effects of THC. Application of the methods used in the currently reviewed studies would be useful and should help define doses and methods of THC administration in different disease conditions. Full article
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