Design and Development of Antibacterial Molecules
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 7
Special Issue Editor
Interests: medicinal chemistry; synthetic organic chemistry; immunology of infectious diseases; medicinal and pharmaceutical chemistry; antibodies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bacteria are the cause of numerous different infectious diseases that have an impact on public health worldwide, causing high morbidity and mortality rates. In the past, many drugs have been developed to prevent and control these infectious diseases; however, in the few last decades, multidrug resistance (MDR) has emerged as a significant public health problem that must be addressed. Despite its importance, current pharmacological treatments have unreliable efficacy against this group of bacteria, denominated ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.). Therefore, there is an urgent need to develop new therapeutic options to combat MDR that are safer and more effective. In the last two decades, new strategies in drug discovery have been implemented to treat infectious diseases. Despite this and the impressive advances in understanding the biology of these diseases, only a limited number of compounds are currently in clinical trials. Therefore, there is an urgent need to develop new therapeutic options that will help to combat MDR, increase treatment effectiveness, decrease cost and facilitate availability. This research topic is seeking the submission of manuscripts focused on novel approaches in the discovery and development of drugs for infectious diseases. By considering both original research and review articles that could have an ever-increasing impact on the drug discovery pipeline, new trends could be discovered that would impact the field. Areas to be covered in this research topic may include, but are not limited to, the following: bioactive compounds; computer-aided drug design; synthesis and biological activity of small molecules; drug targets; and drug repositioning.
Prof. Dr. Gildardo Rivera Sanchez
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bioactive compounds
- computer-aided drug design
- synthesis and biological activity of small molecules
- drug targets
- drug repositioning
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