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Special Issue "Molecules from Multicomponent Reactions"

A special issue of Molbank (ISSN 1422-8599). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Prof. Dr. Luke R. Odell

Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden
Website | E-Mail
Phone: +4618-471 4297
Interests: heterocyclic chemistry; multicomponent reactions; catalysis; medicinal chemistry; synthetic methodology

Special Issue Information

Dear Colleagues,

This Special Issue is devoted to the fascinating topic of multicomponent reactions (MCRs). These reactions are a group of powerful and highly convergent chemical transformations capable of generating enormous structural diversity by reacting three or more starting materials simultaneously. These reactions utilize subtle differences in reactivity between various functional groups to allow a predictable series of reactions to occur in the same vessel, leading to the formation of the desired product. Furthermore, the product incorporates the vast majority of atoms from all starting materials in its framework, making MCRs inherently efficient and sustainable processes. There has been a tremendous amount of interest in MCRs over the last few decades and, as the demands for new and sustainable materials and medicines continue to increase, the topic will undoubtedly remain a focal point for synthetic chemists around the world.

Prof. Dr. Luke R. Odell
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molbank is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multicomponent reaction
  • chemical diversity
  • green chemistry
  • one-pot reactions

Published Papers (1 paper)

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Research

Open AccessShort Note Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Molbank 2018, 2018(4), M1029; https://doi.org/10.3390/M1029
Received: 17 October 2018 / Revised: 4 November 2018 / Accepted: 9 November 2018 / Published: 13 November 2018
PDF Full-text (348 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The Biginelli reaction is a highly versatile reaction that leads to dihydropyrimidinones/thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets. Synthesis of ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate was achieved through the Biginelli reaction using
[...] Read more.
The Biginelli reaction is a highly versatile reaction that leads to dihydropyrimidinones/thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets. Synthesis of ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate was achieved through the Biginelli reaction using a functionalized thiourea. In silico studies demonstrated that the compound title showed good potential for interacting with ecto-5’-nucleotidase, which has been considered as a target in designs for anti-cancer drugs. Full article
(This article belongs to the Special Issue Molecules from Multicomponent Reactions)
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