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Molbank
Volume 2018
Issue 4
10.3390/M1029
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Open AccessShort Note

Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

by
Itamar Luís Gonçalves
1,
Luciano Porto Kagami
1,
Gustavo Machado das Neves
1,
Liliana Rockenbach
1,
Leonardo Davi
1,
Alceu Felipe Soares
1,
Solange Cristina Garcia
2 and
Vera Lucia Eifler-Lima
1,*
1
Laboratório de Síntese Orgânica Medicinal/LaSOM, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul/UFRGS, Av. Ipiranga 2752, Porto Alegre-RS 90610-000, Brazil
2
Laboratório de Toxicologia / LATOX. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul/UFRGS, Av. Ipiranga 2752, Porto Alegre-RS 90610-000, Brazil
*
Author to whom correspondence should be addressed.
Molbank 2018, 2018(4), M1029; https://doi.org/10.3390/M1029
Received: 17 October 2018 / Revised: 4 November 2018 / Accepted: 9 November 2018 / Published: 13 November 2018
(This article belongs to the Special Issue Molecules from Multicomponent Reactions)
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Abstract

The Biginelli reaction is a highly versatile reaction that leads to dihydropyrimidinones/thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets. Synthesis of ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate was achieved through the Biginelli reaction using a functionalized thiourea. In silico studies demonstrated that the compound title showed good potential for interacting with ecto-5’-nucleotidase, which has been considered as a target in designs for anti-cancer drugs. View Full-Text
Keywords: Biginelli reaction; dihydropyrimidin-2-thiones; synthesis; virtual screening; drug design; LaSOM 282, ecto-5’-nucleotidase Biginelli reaction; dihydropyrimidin-2-thiones; synthesis; virtual screening; drug design; LaSOM 282, ecto-5’-nucleotidase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Gonçalves, I.L.; Porto Kagami, L.; Machado das Neves, G.; Rockenbach, L.; Davi, L.; Soares, A.F.; Garcia, S.C.; Eifler-Lima, V.L. Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate. Molbank 2018, 2018, M1029. https://doi.org/10.3390/M1029

AMA Style

Gonçalves IL, Porto Kagami L, Machado das Neves G, Rockenbach L, Davi L, Soares AF, Garcia SC, Eifler-Lima VL. Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate. Molbank. 2018; 2018(4):M1029. https://doi.org/10.3390/M1029

Chicago/Turabian Style

Gonçalves, Itamar L.; Porto Kagami, Luciano; Machado das Neves, Gustavo; Rockenbach, Liliana; Davi, Leonardo; Soares, Alceu F.; Garcia, Solange C.; Eifler-Lima, Vera L. 2018. "Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate" Molbank 2018, no. 4: M1029. https://doi.org/10.3390/M1029

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