Human Papillomaviruses and Human Cytomegalovirus: Updates on Biology, Pathogenesis, and Treatment Options
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 2749
Special Issue Editors
Interests: molecular virology of DNA and RNA viruses; development of antiviral agents with innovative mechanisms of action against DNA and RNA viruses: herpesviruses, human papillomavirus, influenza virus, flavivirus, coronavirus; drug repurposing; development of anti-tumoral agents; inhibition of protein–protein interactions
Special Issue Information
Dear Colleagues,
Among the DNA viruses, human papillomaviruses (HPVs) and human cytomegalovirus (HCMV) represent major human pathogens affecting public health worldwide.
High-risk HPVs are the cause of approximately 5% of cancers worldwide, including cervical, anogenital, and several oropharyngeal cancers. Despite the availability of an effective prophylactic vaccine, there is still an urgent need for an understanding of the molecular mechanisms of HPV-induced pathogenesis and for the development of therapeutic options.
HCMV infects 60% to nearly 80% of the human population and causes life-threatening opportunistic infections in immunocompromised subjects. Moreover, HCMV is the viral leading cause of congenital defects in newborns. Finally, HCMV has been suggested as a cofactor of vascular diseases, immune senescence, and cancer.
This Special Issue aims to describe the latest findings regarding the biology of these two viral pathogens, including entry and replication mechanisms. Moreover, it aims to illustrate the recent advances in the development of both new diagnostic tools and markers and of therapeutic options, including vaccines and antiviral drugs.
Dr. Beatrice Mercorelli
Prof. Dr. Arianna Loregian
Guest Editors
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Keywords
- human papillomavirus
- cervical cancer
- E6 and E7 oncoproteins
- antiviral agents
- vaccine
- human cytomegalovirus
- drug development
- protein–protein interactions inhibitors
- drug repurposing
- viral entry
- viral replication
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