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Antibiotics
Special Issues
Antimicrobial Extracts and Compounds Derived from Plants
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Antimicrobial Extracts and Compounds Derived from Plants

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 642

Special Issue Editor

Dr. Giovanna Simonetti

E-Mail Website
Guest Editor
Department of Environmental Biology, “Sapienza” University of Rome, Rome, Italy
Interests: Candida spp.; Aspergillus spp.; dermatophytes; Malassezia spp.; virulence; antimicrobials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plants, with their extensive repertoire of bioactive compounds, have emerged as a valuable reservoir of novel antimicrobial agents. These phytochemicals—including alkaloids, flavonoids, terpenoids, and essential oils—demonstrate significant efficacy against a wide array of microbial pathogens, encompassing even antibiotic-resistant strains. Unlike conventional antibiotics, plant-derived antimicrobial extracts and compounds often exhibit complex, multifactorial mechanisms of action, which may reduce the likelihood of resistance development. This Special Issue, Antimicrobial Extracts and Compounds Derived from Plants, seeks to showcase pioneering research and progress in this domain. We encourage submissions that delve into the isolation, structural characterization, bioactivity, and mechanisms underlying the antimicrobial properties of plant-derived substances. Manuscripts that explore synergistic interactions with conventional antimicrobials, innovative formulation strategies, and comprehensive assessments of toxicity and safety are particularly welcome. This Special Issue aims to advance the understanding of the potential of natural compounds to serve as effective therapeutic agents, contributing to the development of sustainable and innovative interventions for combating infections and mitigating the global challenge of antimicrobial resistance (AMR).

Dr. Giovanna Simonetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibacterial
  • antifungal
  • plant extract
  • plant compounds
  • antibiotic-resistant strains
  • virulence factors
  • synergistic interactions

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Published Papers (1 paper)

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Research

22 pages, 11874 KiB  
Article
Bactericidal Activities of Nanoemulsion Containing Piper betle L. Leaf and Hydroxychavicol Against Avian Pathogenic Escherichia coli and Modelling Simulation of Hydroxychavicol Against Bacterial Cell Division Proteins
by Kunchaphorn Ratchasong, Phirabhat Saengsawang, Gorawit Yusakul, Fonthip Makkliang, Hemanth Kumar Lakhanapuram, Phitchayapak Wintachai, Thotsapol Thomrongsuwannakij, Ozioma Forstinus Nwabor, Veerasak Punyapornwithaya, Chonticha Romyasamit and Watcharapong Mitsuwan
Antibiotics 2025, 14(8), 788; https://doi.org/10.3390/antibiotics14080788 - 3 Aug 2025
Viewed by 409
Abstract
Background: Avian pathogenic Escherichia coli (APEC) is a leading cause of colibacillosis in poultry. Piper betle L. is a medicinal plant rich in bioactive compounds including hydroxychavicol that possess potent antibacterial activity. This study aimed to investigate the efficacy of a P. [...] Read more.
Background: Avian pathogenic Escherichia coli (APEC) is a leading cause of colibacillosis in poultry. Piper betle L. is a medicinal plant rich in bioactive compounds including hydroxychavicol that possess potent antibacterial activity. This study aimed to investigate the efficacy of a P. betle L. leaf nanoemulsion (NEPE) and hydroxychavicol against multidrug-resistant APEC isolates. Methods: In vitro and in silico analysis of NEPE and hydroxychavicol against APEC were determined. Results: The nanoemulsion exhibited potent antibacterial activity, with MIC and MBC values of 0.06–0.25% v/v and 0.125–0.25% v/v, respectively. The MIC and MBC values of hydroxychavicol against isolates ranged from 0.25 to 1.0 mg/mL. A time–kill assays revealed rapid bactericidal effects of both compounds, achieving a ≥3-log reduction within 4 h at 4 × MIC. Scanning electron microscopy demonstrated that APEC cells treated with hydroxychavicol exhibited filamentous cells with incomplete septa. Molecular docking and dynamics simulations of hydroxychavicol against APEC cell division proteins were investigated. According to the binding energy, hydroxychavicol exhibited the highest affinity with ZapE, FtsW, FtsX, FtsZ, and FtsA, respectively. However, the FtsA protein showed the least protein conformational change throughout the 5000 ns simulation, reflecting a highly stable conformation. Conclusions: These confirm the potential stability of protein and ligand, as supported by molecular dynamics simulation. The results suggested the potential of NEPE and hydroxychavicol, which may have promising antibacterial potential that can be used to inhibit APEC growth. Full article
(This article belongs to the Special Issue Antimicrobial Extracts and Compounds Derived from Plants)
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