Leishmaniasis: Clinical Features and Epidemiology

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Parasitology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1487

Special Issue Editors


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Guest Editor
Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil
Interests: Leishmaniasis
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro 21041-210, Brazil
Interests: Leishmaniasis

Special Issue Information

Dear Colleagues,

Leishmaniasis is caused by more than 20 protozoa of the genus Leishmania. There are more than 90 species of sandflies that transmit the parasite, and about 70 animal species can be a source of transmission, including humans. They are endemic in various regions of the world. There are three main forms of the disease: Cutaneous leishmaniasis, which causes skin lesions on exposed areas, potentially leaving scars with psychological and social repercussions. It is the most common form, with more than 95% of cases occurring in the Americas, the Mediterranean region, the Middle East, and Central Asia. Each year there are between 600,000 and 1 million new cases in the world. Mucosal leishmaniasis is the second form and causes destruction of the mucous membranes of the nose, mouth, and throat. More than 90% of the cases occur in Bolivia, Brazil, Ethiopia, and Peru. The third form, Visceral leishmaniasis (Kala-azar), affects the organs of the hematopoietic system (bone marrow, spleen, lymph nodes) and liver. Every year there are between 50,000 and 90,000 cases worldwide. When left untreated, fatality reaches 95%. Leishmaniasis has undergone epidemiological alterations over time due to environmental and climate changes, deforestation, animal movements, human migrations, social conditions triggered by poverty, violence and armed conflicts, adaptation of sandflies to new environments, and possibly changes in the parasite. As Guest Editors of this Special Issue, we invite you to submit articles related to regional specificities, diagnosis and treatment, clinical features, major risk factors, and the epidemiology of leishmaniasis.

Prof. Dr. Maria Inês Fernandes Pimentel
Prof. Dr. Sandro Javier Bedoya-Pacheco
Guest Editors

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Keywords

  • Leishmaniasis

  • Visceral leishmaniasis
  • Cutaneous leishmaniasis
  • Mucosal leishmaniasis
  • Mucocutaneous leishmaniasis
  • Epidemiology
  • Clinical evolution
  • Prevention and control

Published Papers (1 paper)

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Research

14 pages, 1207 KiB  
Article
Platelet-Derived Microvesicles Contribute to the Pathophysiogenesis of Human Cutaneous Leishmaniasis: A Nano-Flow Cytometric Approach in Plasma Samples from Patients before and under Antimonial Treatment
by Vanessa Fernandes de Abreu Costa, Thaize Quiroga Chometon, Katherine Kelda Gomes de Castro, Melissa Silva Gonçalves Ponte, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra and Alvaro Luiz Bertho
Microorganisms 2024, 12(3), 526; https://doi.org/10.3390/microorganisms12030526 - 6 Mar 2024
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Abstract
Cutaneous leishmaniasis is a neglected tropical disease caused, in Brazil, mainly by Leishmania braziliensis, which is a protozoan transmitted during the blood feeding of infected female sandflies. To control leishmaniasis, the participation of CD4+ Th1 cells together with macrophages, neutrophils, and [...] Read more.
Cutaneous leishmaniasis is a neglected tropical disease caused, in Brazil, mainly by Leishmania braziliensis, which is a protozoan transmitted during the blood feeding of infected female sandflies. To control leishmaniasis, the participation of CD4+ Th1 cells together with macrophages, neutrophils, and other peripheral blood cells, including platelets, is necessary. These anuclear fragments, when activated, produce microvesicles (MVs) that can reach locations outside the blood, carrying molecules responsible for activating pro-inflammatory responses and antigen presentation. Using flow cytometry, this current study evaluated the frequency and concentration of platelet-derived MVs (pMVs) in plasma samples obtained from patients in the acute phase and undergoing treatment, as well as from healthy volunteers. Our results revealed a higher frequency and concentration of pMVs in the plasma of patients with acute CL when compared to all other groups studied. These results highlight the impact of pMVs in modulating the immune response of CL patients, correlating their higher concentrations and frequencies in CL-patient plasmas, with the acute inflammatory status of the disease and their reduction with beneficial results of systemic treatment with antimony. This knowledge is essential to define potential treatment protocols, as well as highlight pMVs as biomarkers for the different clinical stages of CL. Full article
(This article belongs to the Special Issue Leishmaniasis: Clinical Features and Epidemiology)
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