Virulence Regulation and Drug-Resistance Mechanism of Fungal Infection
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 8716
Special Issue Editor
Interests: drug resistance; biofilm; cell wall proteins; Candida spp.; Malassezia spp.; fungal infections
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human fungal pathogens are a commonly underestimated cause of severe diseases associated with high morbidity and mortality. Like other pathogens, their survival and growth in the host, as well as subsequent host damage, is thought to be mediated by virulence factors which set them apart from harmless microbes. Fungi have a remarkable capacity to evolve resistance to antimicrobial agents, threatening the efficacy of the limited arsenal of antimicrobials. Currently, the treatment of fungal infections in humans is limited to the use of a few classes of antifungal drugs. Several studies report that the presence or expression of virulence traits is related to resistance to antimicrobials. Some suggest these relations are antagonistic, while others report enhanced resistance in isolates with high levels of virulence factors. Additionally, the literature indicates that inhibitors of specific virulence may be good therapeutic alternatives for the treatment of fungal infections.
In this Special Issue of Microorganisms, we invite you to send contributions, in the form of original research or review papers, that report the most recent, advanced methods of study concerning any aspects of the expression of virulence factors, in particular in strains of fungi that areresistant to drugs. Such topics might include studies on biofilm formation in resistant strains, or the description of the molecular change of virulence factors in different environments.
Prof. Dr. Letizia Angiolella
Guest Editor
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Keywords
- drug resistance
- yeast
- mould
- biofilm
- dimorphism
- proteinase
- phospholipase
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