Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
4.1
Journals
Microorganisms
Special Issues

Understanding the Interactions Between HIV and Other Infections and Their

...
share announcement

Understanding the Interactions Between HIV and Other Infections and Their Impact on Immune Function

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 15 October 2025 | Viewed by 5126

Special Issue Editors

Prof. Dr. Justyna Dominika Kowalska

E-Mail Website
Guest Editor
Hospital for Infectious Diseases, Department of Adults' Infectious Diseases, Medical University of Warsaw, Warsaw, Poland
Interests: HIV; infection; HIV immunology; HIV prevention; infectious disease epidemiology
Special Issues, Collections and Topics in MDPI journals
Dr. Botond Lakatos

E-Mail Website
Guest Editor
South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, Albert Florian ut 5–7, H-1097 Budapest, Hungary
Interests: HIV; infection; HIV immunology; HIV prevention; infectious disease epidemiology

Special Issue Information

Dear Colleagues,

The late diagnosis of HIV infection remains challenging in many regions of the world. This results in patients presenting AIDS-defining conditions (ADCs), such as tuberculosis, toxoplasmosis, P. jiroveci, or JCV. Despite this, the diagnostics of and therapy for ADC remain understudied in the modern world.

Furthermore, even in patients on effective antiretroviral therapy, residual HIV virus replication is responsible for immune activation, which is broadly linked with a higher frequency of non-HIV-related conditions, such as cardiovascular disease or cancer.

Another important aspect is that many pathogens share the same mode of transmission as HIV, with hepatitis viruses, syphilis, and other sexually transmitted infections being the most pronounced.

The relationship between HIV infection, immune activation, and other pathogens profoundly influences health outcomes, posing significant challenges in clinical management. However, the precise mechanisms of these interactions remain unclear. Understanding how these viruses interact with HIV and impact immune function is essential for developing effective strategies for diagnosis, treatment, and management.

This Special Issue aims to delve into the abovementioned aspects of HIV infection and will cover topics ranging from early diagnosis and effective treatment to exploring the immunological responses and potential risks associated with co-infections.

Prof. Dr. Justyna Dominika Kowalska
Dr. Botond Lakatos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobials
  • natural products
  • anti-biofilm strategies
  • anti-microbial resistance
  • drug delivery
  • formulations

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 7420 KiB  
Communication
Differential Epigenetic Regulation in Uninfected and Tuberculosis–Human Immunodeficiency Virus Co-Infected Patients
by Katlego Mamabolo, Reubina Wadee, Yvonne Perner, Pumza Magangane, Sanelisiwe Thinasonke Duze and Musa Marimani
Microorganisms 2024, 12(5), 1001; https://doi.org/10.3390/microorganisms12051001 - 16 May 2024
Cited by 1 | Viewed by 1310
Abstract
This study aimed to compare the degree of epigenetic modifications between a TB-HIV co-infected cohort and uninfected subjects. Formalin-fixed paraffin-embedded (FFPE) tissues were retrieved from 45 TB-HIV co-infected and 45 control individuals. Real-time PCR was applied to compare the level of expression of [...] Read more.
This study aimed to compare the degree of epigenetic modifications between a TB-HIV co-infected cohort and uninfected subjects. Formalin-fixed paraffin-embedded (FFPE) tissues were retrieved from 45 TB-HIV co-infected and 45 control individuals. Real-time PCR was applied to compare the level of expression of genes involved in epigenetic regulation. The protein multiplex assay was used to assess the degree of protein modification. DNA sequencing was used to determine the evolutionary relationships between the infecting HIV and Mtb strains. Our results indicated a significant increase in the expression of the five candidate genes in the patients with TB-HIV relative to the control cohort. A sharp increase in the degree of histone methylation, acetylation and phosphorylation was observed in TB-HIV co-infected patients. The phylogenetic analysis classified the strains into three distinct HIV clusters and five Mtb clusters. The disparities in the expression profiles of our candidate genes between the TB-HIV cohort and non-TB-HIV group highlights the important role played by various TB and HIV strains in regulating the host gene expression landscape. Full article
(This article belongs to the Special Issue

Understanding the Interactions Between HIV and Other Infections and Their Impact on Immune Function

)
►▼ Show Figures

Figure 1

Review

Jump to: Research

20 pages, 739 KiB  
Review
Gut Microbiome Alteration in HIV/AIDS and the Role of Antiretroviral Therapy—A Scoping Review
by Zsófia Gáspár, Blin Nagavci, Bálint Gergely Szabó and Botond Lakatos
Microorganisms 2024, 12(11), 2221; https://doi.org/10.3390/microorganisms12112221 - 1 Nov 2024
Cited by 1 | Viewed by 2333
Abstract
(1) Background: The gut microbiota plays a crucial role in chronic immune activation associated with human immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS) pathogenesis, non-AIDS-related comorbidities, and mortality among people living with HIV (PLWH). The effects of antiretroviral therapy on the [...] Read more.
(1) Background: The gut microbiota plays a crucial role in chronic immune activation associated with human immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS) pathogenesis, non-AIDS-related comorbidities, and mortality among people living with HIV (PLWH). The effects of antiretroviral therapy on the microbiome remain underexplored. This study aims to map the evidence of the impact of integrase strand transfer inhibitors (INSTI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) on the gut microbiota of PLWH. (2) Methods: A scoping review was conducted using PubMed, Web of Science, and Embase, with reports collected following PRISMA for Scoping Reviews (PRISMA-ScR). (3) Results: Evidence suggests that INSTI-based regimes generally promote the restoration of alpha diversity, bringing it closer to that of seronegative controls, while beta diversity remains largely unchanged. INSTI-based therapies are suggested to be associated with improvements in microbiota composition and a tendency toward reduced inflammatory markers. In contrast, NNRTI-based treatments demonstrate limited recovery of alpha diversity and are linked to an increase in proinflammatory bacteria. (4) Conclusions: Based on the review of the current literature, it is indicated that INSTI-based antiretroviral therapy (ART) therapy facilitates better recovery of the gut microbiome. Full article
(This article belongs to the Special Issue

Understanding the Interactions Between HIV and Other Infections and Their Impact on Immune Function

)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop