Infections in Pregnancy: Microbial Pathogens and Their Impact on Maternal and Fetal Health

A Special Issue of Microorganisms (ISSN 2076-2607) belonging to the section "Medical Microbiology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 670

Editors


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Guest Editor
1. Department of Gynecology and Obstetrics, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-003, Brazil
2. Department of General and Specialized Surgery, School of Medicine and Surgery, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro 22290-240, Brazil
3. Postgraduate Program in Applied Health Sciences, University of Vassouras (Univassouras), Vassouras 27700-000, Brazil
Interests: obstetrics and gynecology; maternal–fetal medicine

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Guest Editor
Department of Obstetrics, Paulista School of Medicine—Federal University of São Paulo (EPM-UNIFESP), São Paulo 04023-062, Brazil
Interests: obstetrics; high-risk pregnancy; perinatology; prenatal diagnosis; ultrasound
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Special Issue Information

Dear Colleagues,

This Special Issue aims to provide a comprehensive overview of the evolving landscape of infections during pregnancy and their impact on maternal, fetal, and neonatal health. We welcome contributions addressing bacterial, viral, fungal, and parasitic infections, including their epidemiology, pathophysiology, diagnosis, prevention, and treatment. Particular attention will be given to emerging infectious diseases, congenital infections, antimicrobial resistance, maternal immunization, placental involvement, and the short- and long-term consequences of maternal infections on pregnancy outcomes. Both basic and clinical research, as well as translational studies and narrative or systematic reviews, are encouraged to promote interdisciplinary discussion and improve maternal-fetal care worldwide.

Prof. Dr. Antônio Rodrigues Braga
Prof. Dr. Edward Araujo Júnior
Guest Editors

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Keywords

  • pregnancy infections
  • maternal-fetal transmission
  • vertical transmission
  • viral infections in pregnancy
  • bacterial infections in pregnancy
  • congenital infections
  • perinatal outcomes
  • placental infection
  • emerging infections
  • antimicrobial therapy in pregnancy

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Published Papers (1 paper)

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Review

26 pages, 2772 KB  
Review
Varicella–Zoster Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Implications in the Vaccination Era
by Isadora Rodrigues Almeida, Camila Silva Belo, Tammy Caram Sabatine, Thamy Cristina Campos, Annie Stefanelli, Liris Naomi Noguchi, Giuliana Augustinelli Sales, Gustavo Yano Callado, Angélica Lemos Debs Diniz, Roberta Granese, Edward Araujo Júnior and Antonio Braga
Microorganisms 2026, 14(8), 1745; https://doi.org/10.3390/microorganisms14081745 - 8 Aug 2026
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Abstract
Infection by the varicella–zoster virus (VZV) during pregnancy is uncommon but clinically relevant, since it may compromise both the mother and the fetus. Although varicella is generally benign and self-limited in childhood, the physiological and immunological changes in pregnancy predispose individuals to more [...] Read more.
Infection by the varicella–zoster virus (VZV) during pregnancy is uncommon but clinically relevant, since it may compromise both the mother and the fetus. Although varicella is generally benign and self-limited in childhood, the physiological and immunological changes in pregnancy predispose individuals to more severe forms of the disease, with pneumonia representing the main maternal complication and a leading cause of morbidity and mortality. Vertical transmission may result in congenital varicella syndrome, the most severe fetal consequence, whose risk is greatest between the 13th and 20th weeks of gestation, or in severe neonatal varicella when maternal infection occurs in the peripartum period. This article presents a narrative review of the literature. To enhance methodological transparency and reproducibility, key principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were applied to the literature search and study selection process. Searches were conducted in the PubMed/MEDLINE and SciELO databases, and 32 studies were included in the narrative synthesis. The review addresses the virology, pathophysiology, and epidemiology of VZV infection, including differences between temperate and tropical regions, as well as its clinical manifestations and maternal, fetal, and neonatal complications. Diagnosis is predominantly clinical, with the polymerase chain reaction being the most sensitive and specific confirmatory method and serology being useful mainly for the assessment of maternal immunity. Management encompasses the assessment of susceptibility, post-exposure prophylaxis according to current guideline recommendations, and early antiviral treatment of established infection. Preconception and postpartum vaccination remain the main preventive strategies. Despite recent advances, important gaps persist regarding prophylactic strategies and the long-term safety of antivirals during pregnancy. Full article
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