Microbial Metabolic Engineering Technology

Dear Colleagues,

Microbial metabolic engineering technology is at the forefront of biotechnological innovation, revolutionizing the production of valuable compounds through the manipulation of metabolic pathways in microorganisms. This cutting-edge research focuses on optimizing microbial cell factories to efficiently synthesize biofuels, pharmaceuticals, chemicals, and other high-value products. By employing genetic engineering techniques, such as gene knockout, overexpression, and pathway optimization, researchers aim to enhance metabolic flux towards desired products while minimizing byproduct formation. Advancements in synthetic biology, systems biology, and computational tools have enabled precise control and fine-tuning of microbial metabolism, leading to improved yields, reduced production costs, and sustainable bioprocesses.

The Special Issue will collect papers on the following research topics:

• Multi-Omics Integration: Integration of genomics, transcriptomics, proteomics, and metabolomics data to gain a comprehensive understanding of microbial metabolism and identify key regulatory nodes for targeted engineering.
• Synthetic Biology Tools: Development of novel synthetic biology tools, such as CRISPR-Cas systems, biosensors, and genetic circuits, for precise manipulation and control of microbial metabolic pathways.
• Host-Pathogen Interactions: Exploration of microbial-host interactions to engineer probiotic strains with enhanced therapeutic properties or develop novel antimicrobial agents targeting specific metabolic vulnerabilities in pathogens.
• Microbiome Engineering: Harnessing microbial communities' metabolic capabilities through microbiome engineering to optimize bioproduction processes, enhance nutrient cycling, and modulate host-microbiome interactions for health benefits.
• Metabolic Network Modeling: Advancements in metabolic network modeling and simulation techniques to predict and optimize cellular metabolism, enabling the design of more efficient microbial cell factories for sustainable bioproduction.
• Enzyme Engineering: Modulating microbial enzyme activities and regulatory functions using recombinant DNA technology.

We invite peer-researchers to contribute their papers to this Special Issue, exploring novel genetic tools, innovative strategies, and metabolic modeling approaches in microbial metabolic engineering technology. This collaborative effort promises a future of customized microbial platforms for diverse industrial applications.

Dr. Kesen Ma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolic engineering
• synthetic biology tools
• genome engineering
• synthetic metabolic pathways
• enzyme engineering