Immunity and Viral Immune Evasion Strategies: Recent Insights

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 61

Special Issue Editors


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Guest Editor
Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy
Interests: virus–host interaction; antiviral immunity; virus interferon resistance; flavivirus, HIV; respiratory infectious diseases; cystic fibrosis; COVID-19 pathogenesis
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy
Interests: virus–host interaction; antiviral immunity; virus interferon resistance; flavivirus, HIV; respiratory infectious diseases

Special Issue Information

Dear Colleagues,

The 21st century has seen many serious outbreaks of viral infectious diseases, mainly caused by zoonotic viruses such as coronaviruses, influenza viruses, and arthropod-borne viruses. Emerging and re-emerging viral diseases have become increasingly frequent, often with no timely or effective countermeasures. Because disease severity results from complex virus–host interactions, understanding viral immunopathogenesis is critical to discover biomarkers and pave the way for novel antiviral targets. Viral genetic variability, tropism, molecular determinants, and host innate and adaptive immune responses all contribute to disease outcome. Symptoms result from direct viral damage—particularly through immune-evasion strategies—or from immune-mediated effects such as inflammation and immune cell activity.

This Special Issue explores the mechanisms underlying virus–host interactions, covering advances in the profiling of molecular events related to viral replication, immune signalling, cellular immune responses, and interaction networks, analysing various acute or chronic viral infections using in vitro and/or in vivo approaches. Insights into these processes will improve our understanding of viral disease outcomes and help to identify the determinants of severe disease and novel therapeutic viral or host targets.

Dr. Carolina Scagnolari
Dr. Federica Frasca
Guest Editors

Manuscript Submission Information

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Keywords

  • virus–host interactions
  • viral immunopathogenesis
  • innate immunity
  • cellular immunity
  • viral genetic variability
  • inflammation
  • viral immune evasion strategies
  • antiviral responses
  • biomarker discovery
  • virulence determinants
  • immune signalling pathways
  • viral persistence

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Published Papers

This special issue is now open for submission.
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