Mycosis and Antifungal Agents

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 901

Special Issue Editors


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Guest Editor
1. American Society for Microbiology (ASM), Washington, DC, USA
2. VSV-Consulting-LATAM, Pucón, Chile
Interests: microbiology; epidemiology; medical mycology; mycosis

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Guest Editor
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile
Interests: medical mycology; environmental mycology; molecular biology
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Special Issue Information

Dear Colleagues,

Mycoses, fungal infections spanning superficial to life-threatening invasive forms, present a growing global health concern. Key pathogens include pathogenic, dimorphic, and opportunistic yeast and filamentous fungi, with infections exacerbated in immunocompromised individuals. Synthetic and natural extract antifungals agents target essential fungal processes, inhibiting ergosterol synthesis, disrupting cell wall glucan synthesis, and compromising membrane integrity. Antifungal resistance is rising, driven by factors like widespread antifungal use, biofilm formation, and genetic mutations leading to altered drug targets or efflux pumps. This resistance compromises treatment efficacy, necessitates alternative therapies, and underscores the urgent need for improved diagnostics, stewardship programs, and the development of novel antifungals. Surveillance and research efforts are crucial to mitigating the impact of resistant fungal infections.

Dr. Victor Silva
Dr. Patrício Christian Godoy-Martínez
Guest Editors

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Keywords

  • mycosis
  • antifungal agents
  • antifungal resistance

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Published Papers (1 paper)

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Research

15 pages, 823 KB  
Article
Infectious Keratitis: A Tertiary Center’s Approach to Diagnosis, Management, and Enhanced Outcomes Through Microbiological Analysis
by Antonio Moramarco, Federico Cassini, Natalie di Geronimo, Giovanni Zanini, Michele Potenza, Matteo Farnè, Viviana Schisa, Erica De Carolis, Margherita Ortalli, Piera Versura, Tiziana Lazzarotto and Luigi Fontana
Microorganisms 2025, 13(10), 2308; https://doi.org/10.3390/microorganisms13102308 - 5 Oct 2025
Viewed by 697
Abstract
Background: The study aimed to assess the diagnostic and therapeutic management of infectious keratitis at a tertiary referral center, focusing on how microbiological analysis influences clinical outcomes. Methods: A retrospective review was conducted on 220 patients (221 eyes) with infectious keratitis treated between [...] Read more.
Background: The study aimed to assess the diagnostic and therapeutic management of infectious keratitis at a tertiary referral center, focusing on how microbiological analysis influences clinical outcomes. Methods: A retrospective review was conducted on 220 patients (221 eyes) with infectious keratitis treated between November 2021 and January 2025. Data collected included clinical presentation, microbiological findings, treatment approaches, and outcomes. Statistical analyses examined the relationships between microbiological results, improvements in visual acuity, and the need for rescue surgery. Results: Bacterial keratitis accounted for 64% of cases, followed by viral (20%), fungal (13%), and Acanthamoeba (3%). Microbiological testing was performed in 107 cases, with a culture positivity rate of 75.7%. Positive microbiological findings were significantly associated with better visual acuity (p = 0.019) and a reduced, though not statistically significant, need for rescue surgery. Use of contact lenses and ocular trauma were independent risk factors for culture positivity. Delayed referral (more than 15 days) was linked to longer treatment durations and a higher likelihood of surgical intervention (p < 0.001). Microbiological diagnosis correlates with improved visual outcomes and a decreased need for surgical procedures. Conclusion: Early referral and targeted therapy are essential for optimizing prognosis. The use of contact lenses and cases of ocular trauma should prompt early diagnostic sampling. Full article
(This article belongs to the Special Issue Mycosis and Antifungal Agents)
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