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Microorganisms
Special Issues
Mycosis and Antifungal Agents
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Mycosis and Antifungal Agents

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1519

Special Issue Editors

Dr. Victor Silva

E-Mail Website
Guest Editor
1. American Society for Microbiology (ASM), Washington, DC, USA
2. VSV-Consulting-LATAM, Pucón, Chile
Interests: microbiology; epidemiology; medical mycology; mycosis
Dr. Patrício Christian Godoy-Martínez

E-Mail Website
Guest Editor
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile
Interests: medical mycology; environmental mycology; molecular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mycoses, fungal infections spanning superficial to life-threatening invasive forms, present a growing global health concern. Key pathogens include pathogenic, dimorphic, and opportunistic yeast and filamentous fungi, with infections exacerbated in immunocompromised individuals. Synthetic and natural extract antifungals agents target essential fungal processes, inhibiting ergosterol synthesis, disrupting cell wall glucan synthesis, and compromising membrane integrity. Antifungal resistance is rising, driven by factors like widespread antifungal use, biofilm formation, and genetic mutations leading to altered drug targets or efflux pumps. This resistance compromises treatment efficacy, necessitates alternative therapies, and underscores the urgent need for improved diagnostics, stewardship programs, and the development of novel antifungals. Surveillance and research efforts are crucial to mitigating the impact of resistant fungal infections.

Dr. Victor Silva
Dr. Patrício Christian Godoy-Martínez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mycosis
  • antifungal agents
  • antifungal resistance

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Published Papers (2 papers)

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Research

13 pages, 2355 KB  
Article
Clinical and Genomic Insights into Antifungal Resistance in Aspergillus Isolates from Thailand
by Thanyarat Onchan, Nattapong Langsiri and Arsa Thammahong
Microorganisms 2025, 13(11), 2495; https://doi.org/10.3390/microorganisms13112495 - 30 Oct 2025
Viewed by 322
Abstract
Aspergillus species are major opportunistic pathogens responsible for invasive aspergillosis, with antifungal resistance posing increasing challenges to their treatment worldwide. We investigated the antifungal susceptibility and genomic features of Aspergillus isolates from sterile clinical specimens collected at a tertiary hospital in Thailand between [...] Read more.
Aspergillus species are major opportunistic pathogens responsible for invasive aspergillosis, with antifungal resistance posing increasing challenges to their treatment worldwide. We investigated the antifungal susceptibility and genomic features of Aspergillus isolates from sterile clinical specimens collected at a tertiary hospital in Thailand between January and December 2023. In total, 24 isolates were identified via culture and tested for amphotericin B and voriconazole susceptibility using CLSI M38 broth microdilution, and whole-genome sequencing was performed on selected isolates to characterize resistance mechanisms. Aspergillus fumigatus was the most frequent species (54%), followed by A. flavus (29%) and other less common species. Voriconazole exhibited potent activity against most isolates, although two A. fumigatus strains showed elevated MICs (2–4 µg/mL), meeting resistance thresholds. One isolate (CUAFU23) was confirmed to harbor the cyp51A TR34/L98H mutation, marking the first identification of this canonical azole resistance mechanism in a clinical specimen from Thailand and supporting earlier environmental findings of azole-resistant A. fumigatus carrying the same allele. Genomic profiling of CUAFU23 further revealed subtle but distinct shifts in domain composition compared with susceptible strains, suggesting broader adaptive changes. The above findings underscore the emergence of azole-resistant A. fumigatus in Thailand and highlight the importance of ongoing surveillance using combined phenotypic and molecular approaches. Full article
(This article belongs to the Special Issue Mycosis and Antifungal Agents)
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15 pages, 824 KB  
Article
Infectious Keratitis: A Tertiary Center’s Approach to Diagnosis, Management, and Enhanced Outcomes Through Microbiological Analysis
by Antonio Moramarco, Federico Cassini, Natalie di Geronimo, Giovanni Zanini, Michele Potenza, Matteo Farnè, Viviana Schisa, Erica De Carolis, Margherita Ortalli, Piera Versura, Tiziana Lazzarotto and Luigi Fontana
Microorganisms 2025, 13(10), 2308; https://doi.org/10.3390/microorganisms13102308 - 5 Oct 2025
Viewed by 951
Abstract
Background: The study aimed to assess the diagnostic and therapeutic management of infectious keratitis at a tertiary referral center, focusing on how microbiological analysis influences clinical outcomes. Methods: A retrospective review was conducted on 220 patients (221 eyes) with infectious keratitis treated between [...] Read more.
Background: The study aimed to assess the diagnostic and therapeutic management of infectious keratitis at a tertiary referral center, focusing on how microbiological analysis influences clinical outcomes. Methods: A retrospective review was conducted on 220 patients (221 eyes) with infectious keratitis treated between November 2021 and January 2025. Data collected included clinical presentation, microbiological findings, treatment approaches, and outcomes. Statistical analyses examined the relationships between microbiological results, improvements in visual acuity, and the need for rescue surgery. Results: Bacterial keratitis accounted for 64% of cases, followed by viral (20%), fungal (13%), and Acanthamoeba (3%). Microbiological testing was performed in 107 cases, with a culture positivity rate of 75.7%. Positive microbiological findings were significantly associated with better visual acuity (p = 0.019) and a reduced, though not statistically significant, need for rescue surgery. Use of contact lenses and ocular trauma were independent risk factors for culture positivity. Delayed referral (more than 15 days) was linked to longer treatment durations and a higher likelihood of surgical intervention (p < 0.001). Microbiological diagnosis correlates with improved visual outcomes and a decreased need for surgical procedures. Conclusion: Early referral and targeted therapy are essential for optimizing prognosis. The use of contact lenses and cases of ocular trauma should prompt early diagnostic sampling. Full article
(This article belongs to the Special Issue Mycosis and Antifungal Agents)
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